- Product Partners
- Supplements Facts
- Scientific References
- Client Reviews
Over 32 Million Servings Sold ...and Counting
AloeCran™ is delivered to your home as a ready to mix powder chock full of nutrients with a wide variety of potential health benefits. You simply add 6oz to 8oz of water (depending on your taste preference) to a scoop of powder, and in a snap you have a great tasting drink.
AloeCran™ doesn’t contain sugar, artificial sweeteners or preservatives that ruin the health benefits of the drink mix. In spite of this, you don’t sacrifice great taste - you just lose the calories and spike in blood sugar.
AloeCran™ contains the organic ACTIValoe® made with the revolutionary Qmatrix™ dehydration process. This delivers powder from the inner gel of the Aloe plant that is still “farm fresh.”? ACTIValoe® has been used in more clinical studies than any other brand of aloe - showing benefits for cholesterol, blood sugar and immune system health, improving nutrient absorption and digestion, providing prebiotic activity and supporting antioxidant levels.
PACran® is made from the whole cranberry - the juice, flesh, skin and seeds. PACran® has been shown to support urinary tract and prostate health. In fact, PACran® was the first cranberry ingredient in the world to receive a government approved claim for urinary tract health. Cranberrries also have been shown to promote heart health and immune system function.
Each serving of AloeCran™ provides 5 grams of soluble fiber from Fibersol®-2. Since only about 50% of Fibersol®-2 ferments in the intestines, it’s much less likely to cause gas or bloating than other fiber products. In over 100 clinical studies and research papers, Fibersol®-2 has been shown to improve elimination and regularity, maintain healthy cholesterol and triglyceride levels and help control the post meal spike in blood sugar. What’s more, Fibersol®-2 promotes satiety by prolonging stomach emptying time and acts as a prebiotic - helping beneficial bacteria flourish in the gut.
ACTIValoe®: Getting the Most Out of the Inner Gel of the Aloe plant
We chose ACTIValoe® for AloeCran™ because it’s made with a breakthrough dehydration technology - called Qmatrix™ - that sets a new standard for Aloe vera quality.
Qmatrix™ removes water from a fresh Aloe leaf using a low temperature/short time (LTST) method that protects heat sensitive Aloe nutrients.
Here’s the ACTIValoe® bottom line: when you add water to make a glass of AloeCran™, the Aloe vera will still be “farm fresh” - as pure and potent as if you freshly squeezed the juice from an Aloe leaf.
And ACTIValoe® is 100% organic - from start to finish absolutely no chemicals, pesticides or preservatives are used. There’s a reason why ACTIValoe® has been used in more clinical studies than any other Aloe vera ingredient - it’s simply “best in class.”
Each serving of ACTIValoe® is guaranteed to provide a minimum of 10% polysaccharides - the most important nutrients in Aloe vera.
What’s more, ACTIValoe® is certified for content and purity by the International Aloe Science Council (IASC).
On top of this, ACTIValoe® made with Qmatrix™, is the first and only Aloe vera ingredient to achieve GRAS status with the FDA as a food ingredient. ACTIValoe® was the subject of extensive safety studies conducted over two years that provided scientific support for the FDA.
So regardless of what health benefits you seek from Aloe vera - digestion and intestinal health, blood sugar control, or heart health - the presence of Qmatrix™ ACTIValoe® in AloeCran™ provides superior potency.
PACran®: Provides the Goodnes Found in WHOLE Cranberry
Proanthocyanidins (PACs) are the phytonutrients believed to be mainly responsible for many of the health benefits associated with cranberries. Science has shown that cranberries contain unique A-type PACs, seldom found elsewhere in nature, that help promote urinary tract, gastrointestinal, and cardiovascular health.
This led many other companies to isolate PACs and sell ingredients with high PAC concentrations - the thought being more must be better.
However, recent research has found that to maximize benefits from cranberry fruit, it’s best to get the nutrients from the entire cranberry - as nature made it - not just PAC fractions.
That’s why AloeCran™ contains the world’s premier whole cranberry ingredient named PACran® (pronounced “pack cran”).
PACran® is an all natural, 100% cranberry fruit ingredient. With PACran®, you get every part of the cranberry - the juice, flesh, skin and seeds.
Better yet, PACran®’s benefits have been demonstrated in multiple clinical studies conducted in the U.S and internationally.
One of the keys to PACran®’s potency is the type of cranberries used - which are the rare “Early Black” cranberries. In fact, these berries are harvested from cranberry bogs in Massachusetts that are over 100 years old.
Early Blacks are used because they’re the most potent cranberries around - and are the reason why PACran® contains 1.5% PACs, which is twice as much as other whole cranberry powders.
It’s also noteworthy that PACran® contains the first cranberry ingredient in the world to receive a government approved claim for urinary tract health.
Fibersol®-2: Helping to “Bridge” Your Daily Fiber Gap
A recent survey by the International Food Information Council found that 72% of Americans are trying to consume more fiber each day.
And for good reason - we don’t get close to what we need! Here is the simple math on fiber:
Both the USDA and the Institute of Medicine advise that adults get 14 grams of fiber for every 1,000 calories consumed. So if you eat the typical 2,000 calories each day, you should get 28 grams of fiber.
How much fiber does the aver-age American get?
Only about 12g to 16g - we struggle to get HALF of what is needed.
And in case you don’t know, fiber is needed to i) manage cholesterol and triglyceride levels, ii) keep blood sugar in a good range, iii) improve intestinal health and elimination, iv) keep weight and fat under control and v) boost immune health.
Before you choose a supplement, you should know about a couple of the problems with the fiber in many supplements.
For starters, there is the taste. Most fibers taste really bad - so you definitely don’t look forward to eating or drinking them.
Worse is the extra gas and acid release that can cause you needless discomfort and bloating. This happens because almost 100% of these fiber ingredients ferment in the intestines.
We considered these concerns and choose to use Fibersol®-2, a soluble dietary fiber, in AloeCran™.
One of the great features of FiberSol®-2 is that it’s odorless and tasteless. This is in contrast to other fiber supplements that often have a “chalky” or otherwise nasty taste.
Even better, only about 50% of FiberSol®-2 ferments in your large intestine (providing prebiotic activity) . So you don’t have to worry about Fibersol®-2 causing excess gas, bloating or releasing acid in your gut.
What’s more, Fibersol®-2 is a completely “clean” fiber. It is made from Iowa corn and is completely free of bacteria, GMO proteins, toxins and harmful pathogens. Using enzymes, the natural bonds between glucose molecules in corn starch are “strengthened” to withstand the digestion process - making Fibersol®-2 an indigestible carbohydrate, or dietary fiber.
The icing on the cake is there have been over 100 research papers and clinical studies published on Fibersol®-2 in the last two decades.
And this work has shown that Fibersol®-2 provides just about all of the health benefits you want from fiber as well demonstrating an impressive safety profile.
Dietary Supplement / Net Wt. 201 g (7.09 oz)
Serving Size: 1 Scoop (6.7 g)
Servings per Container: 30
|Amount Per Serving||% Daily Value|
|Total Carbohydrate||5 g||2%*|
|Dietary Fiber||5 g||20%*|
|ACTIValoe® aloe vera gel (from 200x concentrate)||200 mg||†|
|PACran® whole cranberry powder||250 mg||†|
|Fibersol®-2 (resistant glucose polymers)||5 g||†|
|Malic acid/algae complex Malic acid, Dunaliella salina red algae||200 mg||†|
|Stevia Leaf extract||70 mg||†|
|Luo han guo fruit extract||12 mg||†|
*Percent daily values are based on a 2,000 calorie diet. † Daily value not established.
Other ingredients: beet juice powder (color), natural flavors, silica, potasssium citrate, gum acacia.
Fibersol®-2 is a registered trademark of Matsutani America, Inc.
PACran® is a registered trademark of Decas Botanical Synergies, LLC.
ACTIValoe® is a trademark of Aloecorp, Inc.
Each refreshing scoop (scoop provided inside each jar) of AloeCran™ Powder Mix combines 200 mg of ACTIValoe® 200:1 aloe vera leaf gel concentrate, 250 mg of PACran®, which has a guaranteed high level of potent cranberry proanthocyanidins, and 5g of the patented fiber Fibersol®-2†.
SUGGESTED USE: As a dietary supplement, add one (1) scoop (filled to line) to 6 fl oz. to 8 fl oz. of cold water and mix well. Maximum benefits usually occur with sustained use.
Use AloeCran™ to help support healthy digestion, a healthy urinary tract and for overall health and well-being. Fibersol®-2 helps maintain normal, healthy levels of serum cholesterol, blood triglycerides and blood sugar. Enjoy as often as you would like to rejuvenate, refresh and invigorate from head to toe!†
Keep out of reach of children.
Store at 15-30° C (59-86° F).
Protect from heat, light and moisture.
Do not purchase if seal is broken.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- Gluten Free
- Assembled in the USA
Manufactured for and Distributed by: NatureCity®
Boca Raton, FL 33487 www.naturecity.com
To re-order call toll free 1-800-593-2563
Devaraj S, Yimam M, Brownell LA, Jialal I, Singh S, Jia Q. “Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome.” Metabolic Syndrome and Related Disorders. 2013 Feb;11(1):35-40.
Yun JM, Singh S, Jialal R, Rockwood J, Jialal I, Devaraj S. “A randomized placebo-controlled crossover trial of aloe vera on bioavailability of vitamins C and B(12), blood glucose, and lipid profile in healthy human subjects.” Journal of Dietary Supplements. 2010 Jun;7(2):145-53.
Williams L, Burdock G, Shin E, Kim S, Jo T, Jones K, Matulka R “Safety studies conducted on a proprietary high-purity aloe vera inner leaf fillet preparation, Qmatrix” Regulatory Toxicology and Pharmacology. 2010 Jun;57(1):90-8
Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH. “Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo.” Annals of Dermatology. 2009 Feb;21(1):6-11.
Devaraj S, Jialal R, Jialal I, Rockwood J “A pilot randomized placebo controlled trial of 2 Aloe vera supplements in patients with pre-diabetes/metabolic syndrome” Planta Medica 2008; 74 - SL77
The Catholic University of Korea, Kangnam St. Mary Hospital “A single center, randomized, double-blind, placebo controlled human test to evaluate the efficacy and safety of Aloe regarding the immunity enhancing effect” Unpublished data 2007
Vinson JA, Al Kharrat H, Andreoli L. “Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.” Phytomedicine. 2005 Nov;12(10):760-5.
Other Aloe Vera
Singab AN, El-Hefnawy HM, Esmat A, Gad HA, Nazeam JA. “A Systemic Review on Aloe arborescens Pharmacological Profile: Biological Activities and Pilot Clinical Trials.” Phytotherapy Research. 2015 Dec;29(12):1858-67.
Panahi Y, Khedmat H, Valizadegan G, Mohtashami R, Sahebkar A.Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial. Journal of Traditional Chinese Medicine.2015 Dec;35(6):632-6.
Pothuraju R, Sharma RK, Onteru SK, Singh S, Hussain SA. “Hypoglycemic and Hypolipidemic Effects of Aloe vera Extract Preparations: A Review.” Phytotherapy Research. 2015 Dec 14.
Pradeep AR, Garg V, Raju A, Singh P. “Adjunctive Local Delivery of Aloe Vera Gel in Type 2 Diabetics With Chronic Periodontitis : A Randomized Controlled Clinical Trial.” Journal of Periodontology. 2015 Oct 8:1-10.
Kumar A, Sunkara MS, Pantareddy I, Sudhakar S. “Comparison of Plaque Inhibiting Efficacies of Aloe Vera and Propolis Tooth Gels: A Randomized PCR Study.” Journal of Clinical Diagnostic Research. 2015 Sep;9(9):ZC01-3.
Størsrud S, Pontén I, Simrén M. “A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study.” Journal of Gastrointestinal and Liver Diseases. 2015 Sep;24(3):275-80.
Chandra Shekar BR, Nagarajappa R, Suma S, Thakur R. “Herbal extracts in oral health care - A review of the current scenario and its future needs.” Pharmacognosy Reviews. 2015 Jul-Dec;9(18):87-92.
Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. “Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial.” Journal of Diabetes & Metabolic Disorders. 2015 Apr 9;14:22.
Radha MH, Laxmipriya NP. “Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review.” Journal of Traditional and Complementary Medicine. 2014 Dec 23;5(1):21-6.
Gupta RK, Gupta D, Bhaskar DJ, Yadav A, Obaid K, Mishra S. “Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial.” Ethiopian Journal of Health Sciences. 2014 Apr;24(2):139-44.
Budai MM, Varga A, Milesz S, Tözsér J, Benkö S. “Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.” Molecular Immunology. 2013 Dec;56(4):471-9.
Sahu P, Giri D, Singh R, Pandey P, Gupta S, Shrivastava A, Kumar A, Pandey K. “Therapeutic and Medicinal Uses of Aloe vera: A Review.” Pharmacology & Pharmacy. 2013 Nov;Vol.4 No.8.
Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. “Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial.” Nutrition. 2013 Sep;29(9):1110-4.
Patil BA, Bhaskar HP, Pol JS, Sodhi A, Madhu AV. “Aloe vera as cure for lichen planus.” The New York State Dental Journal. 2013 Aug-Sep;79(5):65-8.
López-Jornet P, Camacho-Alonso F, Molino-Pagan D. “Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome.” Journal of Oral Pathology & Medicine. 2013 Apr;42(4):295-301.
Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, Woolger JM, Ali KH. “The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease.” Journal of Alzheimer's Disease. 2013 Jan;33(2):393-406.
Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. “Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.” Planta Med. 2012 Mar;78(4):311-6.
Mansourian A, Momen-Heravi F, Saheb-Jamee M, Esfehani M, Khalilzadeh O, Momen-Beitollahi J. “Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial.”
The American Journal of the Medical Sciences. 2011 Dec;342(6):447-51.
Yagi A, Hegazy S, Kabbash A, Wahab EA. “Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients.” Saudi Pharmaceutical Journal. 2009 Jul;17(3):209-15.
Ulbricht C, Armstrong J, Basch E, Basch S, Bent S, Dacey C, Dalton S, Foppa I, Giese N, Hammerness P, Kirkwood C, Sollars D, Tanguay-Colucci S, Weissner W. “An evidence-based systematic review of Aloe vera by the natural standard research collaboration.” Journal of Herbal Pharmacotherapy. 2007;7(3-4):279-323.
Tanaka M, Misawa E, Ito Y, Habara N, Nomaguchi K, Yamada M, et al. “Identification of five phytosterols from Aloe vera gel as anti-diabetic Compounds”. Biological and Pharmaceutical Bulletin. 2006;29(7):1418–22.
Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS. “Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis.” Alimentary Pharmacology & Therapeutics. 2004 Apr 1;19(7):739-47.
Vázquez B, Avila G, Segura D, Escalante B. “Antiinflammatory activity of extracts from Aloe vera gel.” Journal of Ethnopharmacology. 1996 Dec;55(1):69-75.
Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. “Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus.” Phytomedicine. 1996 Nov;3(3):241-3.
Danhof I. “Aloe Through the Ages, Volume 1”. Omnimedicus Press. 1987.
Bunyapraphatsara N et al. "Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide." Phytomedicine. 3, 3:245-248, 1996.
Bland J. “Effect of orally consumed Aloe Vera juice on gastrointestinal function in normal humans”. Preventative Medicine. March/April, 1985.
Agarwal OP. "Prevention of atheromatous heart disease." Angiology. 36, 8:485-492, 1985.
Danhof, I.E., McAnally, B.H. “Stabilized Aloe Vera: Effect on Human Skin Cells”. Drug & Cosmetic. Industry. (1983) 133, 52-106
Fromentin E, Vostalova J, Vidlar A, Galandakova A, Vrbkova J, Ulrichova J, Student V, Simanek V. “A randomized, double-blind, placebo-controlled clinical trial to investigate the efficacy of cranberry fruit powder (Pacran®) in the prevention of recurrent urinary tract infection in women.” The FASEB Journal. 2014 Apr;Vol. 28 no. 1 Supplement 639.4.
Sengupta K, Alluri K, Golakoti T, Gottumukkala G, Raavi J, Kotchrlakota L, Sigalan S, Dey D, Ghosh S, Chatterjee A. “A Randomized, Double Blind, Controlled, Dose Dependent Clinical Trial to Evaluate the Efficacy of a Proanthocyanidin Standardized Whole Cranberry (Vaccinium macrocarpon) Powder on Infections of the Urinary Tract.” Current Bioactive Compounds. March 2011, Volume 7, Number 1, , pp. 39-46(8).
Vidlar A, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V. “The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms.” British Journal of Nutrition. 2010 Oct;104(8):1181-9.
Howell, A. “Assessment of bacterial anti-adhesion activity of PACran® in human urine against P-type uropathogenic Escherichia coli. A randomized, placebo-controlled, ex vivo, double-blind, crossover trial” Rutgers University. 2012 Unpublished data.
Howell, A. “Bacterial Anti-adhesion Activity of Human Urine Following 27% Cranberry Juice Cocktail vs. PACran® Capsule Consumption,” Rutgers University. 2009 Unpublished data.
Howell, A. “Bacterial Anti-adhesion Activity of Human Urine: PACran® Capsule vs. TheraCran®* Capsule Consumption,” Rutgers University. 2009 Unpublished data.
Novotny JA, Baer DJ, Khoo C, Gebauer SK, Charron CS. “Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults.” Journal of Nutrition. 2015 Jun;145(6):1185-93.
Foxman B, Cronenwett AE, Spino C, Berger MB, Morgan DM. “Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial.” American Journal of Obstetrics & Gynecology. 2015 Aug;213(2):194.e1-8.
Caljouw MA, van den Hout WB, Putter H, Achterberg WP, Cools HJ, Gussekloo J. “Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilities.” Journal of the American Geriatrics Societry. 2014 Jan;62(1):103-10.
Ledda A, Bottari A, Luzzi R, Belcaro G, Hu S, Dugall M, Hosoi M, Ippolito E, Corsi M, Gizzi G, Morazzoni P, Riva A, Giacomelli L, Togni S. “Cranberry supplementation in the prevention of non-severe lower urinary tract infections: a pilot study.” European Review for Medical and Pharmacological Sciences. 2015 Jan;19(1):77-80.
Mathison BD, Kimble LL, Kaspar KL, Khoo C, Chew BP. “Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial.” Nutrition Research. 2014 May;34(5):420-7.
Nantz MP, Rowe CA, Muller C, Creasy R, Colee J, Khoo C, Percival SS. “Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study.” Nutrition Journal. 2013 Dec 13;12:161.
Duffey KJ, Sutherland LA. “Adult cranberry beverage consumers have healthier macronutrient intakes and measures of body composition compared to non-consumers: National Health and Nutrition Examination Survey (NHANES) 2005-2008.” Nutrients. 2013 Dec 4;5(12):4938-49.
Simão TN, Lozovoy MA, Simão AN, Oliveira SR, Venturini D, Morimoto HK, Miglioranza LH, Dichi I. “Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome.” British Journal of Nutrition. 2013 Nov;110(10):1885-94.
Afshar K, Stothers L, Scott H, MacNeily AE. “Cranberry juice for the prevention of pediatric urinary tract infection: a randomized controlled trial.” The Journal of Urology. 2012 Oct;188(4 Suppl):1584-7.
Bianco L, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M.”Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents.” Journal of the American Geriatrics Society. 2012 Jun;60(6):1180-1.
Dohadwala MM, Holbrook M, Hamburg NM, Shenouda SM, Chung WB, Titas M, Kluge MA, Wang N, Palmisano J, Milbury PE, Blumberg JB, Vita JA. “Effects of cranberry juice consumption on vascular function in patients with coronary artery disease.” The American Journal of Clinical Nutrition. 2011 May;93(5):934-40.
Basu A, Betts NM, Ortiz J, Simmons B, Wu M, Lyons TJ. “Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome.” Nutrition Research. 2011 Mar;31(3):190-6.
Bonifait L, Grenier D. “Cranberry polyphenols: potential benefits for dental caries and periodontal disease.” 2010 Oct;76:a130.
Tempera G, Corsello S, Genovese C, Caruso FE, Nicolosi D. “Inhibitory activity of cranberry extract on the bacterial adhesiveness in the urine of women: an ex-vivo study.” International Journal of Immunopathology and Pharmacology. 2010 Apr-Jun;23(2):611-8.
Ferrara P, Romaniello L, Vitelli O, Gatto A, Serva M, Cataldi L. “Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children.” Scandinavian Journal of Urology. 2009 Jan;43(5):369-72.
Valentova K, Stejskal D, Bednar P, Vostalova J, Cíhalík C, Vecerova R, Koukalova D, Kolar M, Reichenbach R, Sknouril L, Ulrichova J, Simanek V. “Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial.” Journal of Agricultural and Food Chemistry. 2007 Apr 18;55(8):3217-24.
Ohnishi R, Ito H, Kasajima N, Kaneda M, Kariyama R, Kumon H, Hatano T, Yoshida T. “Urinary excretion of anthocyanins in humans after cranberry juice ingestion.” Bioscience, Biotechnology, and Biochemistry. 2006 Jul;70(7):1681-7.
Di Martino P, Agniel R, David K, Templer C, Gaillard JL, Denys P, Botto H. “Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: a double-blind randomized placebo-controlled cross-over trial.” World Journal of Urology. 2006 Feb;24(1):21-7.
Greenberg J, Newmann S, Howell A. “Consumption of Sweetened Dried Cranberries Versus Unsweetened Raisins for Inhibition of Uropathogenic Escherichia coli Adhesion in Human Urine: A Pilot Study.” The Journal of Alternative and Complementary Medicine. October 2005, 11(5): 875-878.
Stothers L. “A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women.” The Canadian Journal of Urology. 2002 Jun;9(3):1558-62.
Intestinal Regularity and Prebiotic Effect
Baer DJ, Stote KS, Henderson T, Paul DR, Okuma K, Tagami H, Kanahori S, Gordon DT, Rumpler WV, Ukhanova M, Culpepper T, Wang X, Mai V. “The metabolizable energy of dietary resistant maltodextrin is variable and alters fecal microbiota composition in adult men.” Journal of Nutrition, 2014, 144 (7), 1023-1029.
Kishimoto Y, Kanahori S, Sakano K, Ebihara S. “The maximum single dose of resistant maltodextrin that does not cause diarrhea in humans.” Journal of Nutritional Science and Vitaminology(Tokyo). 2013;59(4):352-7.
Ukhanova M, Culpepper T, Baer D, Gordon D, Kanahori S, Valentine J, Neu J, Sun Y, Wang X, Mai V. “Gut microbiota correlates with energy gain from dietary fibre and appears to be associated with acute and chronic intestinal diseases.” Clinical Microbiology and Infection, 2012, 18(Suppl. 4), 62-66.
Fastinger ND, Karr-Lilienthal LK, Spears JK, Swanson KS, ZInn KE, Nava GM, Ohkuma K, Kanahori S, Gordon DT, Fahey GC. “A Novel Resistant Maltodextrin Alters Gastrointestinal Tolerance Factors, Fecal Characteristics, and Fecal Microbiota in Healthy Adult Humans.” Journal of the American College of Nutrition, 2008, 2, 356-366.
Pylkas AM, Juneja LR, Slavin JL. “Comparison of Different Fibers for In Vitro Production of Short Chain Fatty Acids by Intestinal Microflora.” Journal of Medicinal Food, 2005, 8(1), 113-116.
Furukawa T, Yonekawa S, Kurosawa M. “Effects Prepared Cocoa Powder Containing Indigestible Dextrin on Human Defecation.” Journal of the Japanese Council for Advanced Food Ingredients Research, 2004, 7 (1), 55-62.
Takagaki K, Ikeguchi M, Ariura Y, Fujinaga N, Ishibashi Y, Sugawa-Katayama Y. “The effect of AOJIRU drink powder containing indigestible dextrin on defecation frequency and fecal characteristics.” Journal of Nutritional Food, 2001, 4 (4), 29-35.
Unno T, Nagata K, Suzuki N, Yayabe F, Horiguchi T. “Effect of a vegetable drink supplemented with indigestible dextrin on defecation in females.” Journal of Nutritional Food, 2001, 4 (4), 21-27.
Yamamoto Y, Nishida T, Sone Y. “The effect of ingestion of beverage supplemented with indigestible dextrin on human defecation.” Journal of Nutritional Food, 2000, 3 (2), 29-36.
Sato M, Oishi Y, Ohmori T, Morimatsu F, Inage H, Watanabe I, Yamada R, Kimura S. “Effect of sausage containing indigestible dextrin on fecal amount and defecation frequency.” Journal of Nutritional Food, 2000, 3 (4), 55-62.
Sato M, Oishi Y, Ohmori T, Morimatsu F, Inage H, Watanabe I, Yamada R, Kimura S. “Effect of cooked and cured loin-roll ham containing indigestible dextrin on fecal amount and defecation frequency.” Journal of Nutritional Food, 2000, 3 (4), 47-54
Tanaka Y, Mizutani H, Yamada S, Iwata Y, Katada T, Nakata S. “Beneficial effect of a vegetable drink containing indigestible dextrin on defecation in women with constipation.” Journal of Nutritional Food, 2000, 3 (4), 39-46.
Unno T, Nagata K, Yayabe F, Horiguchi T. “Effect of drinks supplemented with indigestible dextrin on defecation in human.” Journal of Nutritional Food, 2000, 3 (4), 31-38.
Shi S, Kato K, Kusuhara S. “The Effects of rise crackers containing indigestible dextrin on female defecation.” Journal of Nutritional Food, 2000, 3 (2), 37-44.
Ogiso H, Ito Y, Hayashi K. “Effects of Cookies Containing Indigestible Dextrin on Defecation and Fecal Condition in Human Subjects.” Journal of Japanese Association for Dietary Fiber Research, 1999, 3 (2), 79-83.
Umekawa T, Fujii K, Matuoka T. “Effect of drinks supplemented with indigestible-dextrin on fecal amount.” Journal of Nutritional Food, 1999, 2 (2), 52-57.
Inaki M, Fujii S, Iino H. “Effects of the administration of soft drink containing indigestible dextrin on defecation frequency and fecal characteristics of Japanese healthy female volunteers.” Journal of Nutritional Food, 1999, 2 (1), 44-51.
Kimura K, Ida M, Matoba T. “Effect of Jelly Drink Containing Dietary Fiber on Human Defecation.” Journal of Nutritional Food, 1998, 1 (3/4), 12-19.
Fukuoka Takano Hospital/ Coloproctology Center, Takano Hospital. “Effectiveness of Dietary Fiber on Irritable Bowel Syndrome (IBS).”Japanese Journal for Psychosomatic Medicine, 1994, 34(Abstract from Meeting), 97.
Satouchi M, Wakabayashi S, Ohkuma K, Fujiwara K, Matsuoka A. “Effects of Indigestible Dextrine on Bowel Movements.” Japanese Journal of Nutrition, 1993, 51, 31-37.
Blood Sugar Metabolism
Kishimoto Y, Hayashi N, Yamada T, Yuba K, Yamamoto K. “Favorable Effect of Resistant Maltodextrin on Postprandial Blood Glucose, Insulin and Triglyceride Levels.” Japanese Pharmacology & Therapeutics 2009, 37, 277-283.
Livesey G, Tagami H. “Interventions to lower the glycemic response to carbohydrate foods with a low-viscosity fiber (resistant maltodextrin): meta-analysis of randomized controlled trials.” American Journal of Clinical Nutrition, 2009, 89: 114-125.
Sonoki H. “Effects of Dietary Fiber Enriched Liquid Formula on Postprandial Glycemic Parameters.” ILSI Japan, 2008, 95, 10-17.
Unno T, Nagata K, Horiguchi T. “Effects of green tea supplemented with indigestible dextrin on postprandial levels of blood glucose and insulin in human subjects.” Journal of Nutritional Food, 2002, 5(2), 31-39.
Wolf BW, Wolever TMS, Bolognesi C, Zinker BA, Garleb KA .“Glycemic response to a rapidly digested starch is not affected by the addition of an indigestible dextrin in humans.” Nutrition Research, 2001, 21, 1099-1106.
Sakizaki K, Yonezawa H. “Efficacy of packed boiled rice containing indigestible dextrin on moderating the rise of postprandial blood glucose levels, and safety of long-term administration.” Journal of Nutritional Food, 2001, 4 (3), 81-88.
Maeda H, Yasuda K, Ohara I. “Effects of indigestible dextrin-containing soft drinks on postprandial blood glucose levels in healthy human subjects.” Journal of Nutritional Food, 2001, 4 (3), 73-79.
Shioda N, Shimizu M, Shimizu Y, Ono K, Sawanoi T, Morimatsu F, Uchikawa T, Yamanouchi T, Yamada R. “Effects of yogurt drink containing indigestible dextrin on postprandial blood glucose levels in Japanese healthy volunteers.” Journal of Nutritional Food, 2001, 4 (2), 7-18.
Mizushima N, Chiba Y, Katsuyama S, Kobayashi C. “Effect of long-term ingestion of indigestible dextrin-containing soft drinks on safety and blood glucose levels.” Journal of Nutritional Food, 2000, 3 (3), 75-82.
Wakabayashi S, Kishimoto Y, Nanbu S, Matsuoka A. “Effect of indigestible dextrin on postprandial rise in blood glucose levels in man.” Journal of Japanese Association for Dietary Fiber Research, 1999, 3 (1), 13-19.
Uno K, Takagi K, Akaza M, Takagi N, Yoshio N, Maeda I. “Effect of indigestible dextrin-containing tofu on blood glucose level in healthy human subjects.” Journal of Nutritional Food, 1999, 2 (4), 25-31.
Mizushima N, Chiba Y, Katsuyama S, Daigo Y, Kobayashi C. “Effect of indigestible dextrin-containing soft drinks on blood glucose level in healthy human subjects.” Journal of Nutritional Food, 1999, 2 (4), 17-23.
Shinohara H, Tsuji H, Seto A. “Effects of indigestible dextrin-containing green tea on blood glucose level in healthy human subjects.” Journal of Nutritional Food, 1999, 2 (1), 52-56.
Ueda Y, Wakabayashi S, Matsuoka A. “Effects of Indigestible Dextrin on Blood Glucose and Urine C-peptide Levels Following Sucrose Loading.” Journal of the Japanese Diabetes Society, 1993, 36,715-723.
Cholesterol and Triglycerides
Kobayashi Y, Kaneko Y, Katayama M, Itakura H. “Effect of Carbonated Beverage Containing Resistant Maltodextrin on postprandial Serum Triglyceride and the Safety Evaluation of Long-term or Excessive Intake of the Beverage.” Japanese Pharmacology & Therapeutics 2013, 41, 863-875.
Hashizume C, Kishimoto Y, Kanahori S, Yamamoto T, Okuma K, Yamamoto K. “Improvement Effect of Resistant Maltodextrin in Humans with Metabolic Syndrome by Continuous Administration.” Journal of Nutritional Science and Vitaminology, 2012, 58, 423-430.
Tanaka T, Nakamura J, Kitagawa Y, Shibata H, Sugimura H. “Effect of carbonated beverage containing resistant maltodextrin on postprandial serum triglyceride –A randomized, double-blind, placebo-controlled, crossover study.” Japanese Pharmacology & Therapeutics, 2011, 39, 813-821.
Suzuki M, Wakabayashi H, Yoshida A, Deuchi K, Shioya N, Itakura H. “Effect of Carbonated Beverage Containing Indigestible Dextrin on Postprandial serum Triglyceride.” Japanese Pharmacology & Therapeutics 2010, 38, 637-643.
Sato F, Saito A, Miyawaki H, Takehara I, Miyakoshi T, Takahashi N “Effect of Beverage Containing Resistant Maltodextrin on Postprandial Serum Triglyceride and the Safety Evaluation of Long-term or Excessive Intake of the Beverage.” Japanese Pharmacology & Therapeutics, 2009, 37, 857-866.
Hironaka T, Kishimoto Y, Matsubara H, Matsuoka Y. “Inhibitory Effect of Tea Containing Resistant Maltodextrin on the Elevation of Serum Triglyceride after Intake of Lipid.” Japanese Pharmacology & Therapeutics 2008, 36, 445-451.
Kishimoto Y, Yoshikawa Y, Miyazato S, Oga H, Ymada T, Tagami H, Hashizume C, Yamamoto K. “Effect of Resistant Maltodextrin on Digestion and Absorption of Lipids”
Journal of Health Science, 2009, 55(5), 838-844.
Kishimoto Y, Oga H, Tagami H, Okuma K, Gordon DT. “Suppressive effect of resistant maltodextrin on postprandial blood triacylglycerol elevation.” European Journal of Nutrition, 2007, 46, 133-138.
Gordon DT. “The effects of resistant maltodextrin on blood glucose, insulin and triacylglyceride levels, and fat accumulation after meal feeding in humans.” Dietary fibre components and functions, 2007, pp 305-322.
Okuma K and Kishimoto Y. “Effects of resistant maltodextrin on metabolism of glucose and lipids.” Dietary Fibre - bio-active carbohydrates for food and feed, J.W. van der Kamp et al. (Eds), Wageningen Academic Publishers, The Netherlands, 2004, pp 219-230.
Kajimoto O, Henmi M, Sano J, Tsuda R, Hatori M, Ohki K, Hirata H, Takahashi T, Tsuboi M, Hata Y. “Effects of a tea beverage containing indigestible dextrin on the serum triglyceride level in subjects with mild hypertriglyceridemia.” Journal of Nutritional Food, 2002, 5 (3), 117-130.
Kajimoto O, H Hirata, T Takahashi, M Henmi, F Morimoto, K Ohki “Beneficial effects of a new indigestible dextrin-containing beverage on lipid metabolism and obesity-related parameters.” Journal of Nutritional Food, 2000, 3 (3), 47-58.
Kishimoto Y, Wakabayashi S, Yuba K. “Effects of instant miso-soup containing indigestible dextrin on moderating the rise of postprandial blood glucose levels, and safety of long-term administration.” Journal of Nutritional Food, 2000, 3 (2), 19-27.
Kawasaki F, Matsuda M, Hiramatsu T, Hiroe K, Kawahara K, Moriya K, Kaku K “Efficacy of tea drink containing indigestible dextrin.” Journal of Nutritional Food, 2000, 3 (1), 65-72.
Tokunaga K, Matsuoka A. “Effects of a Food for Specified Health Use (FOSHU) which contains indigestible dextrin as an effective ingredient on glucose and lipid metabolism.” Journal of the Japanese Diabetes Society, 1999, 42, 61-65.
McCarron DA, Oparil S, Chait A, Haynes RB, Kris-Etherton P, Stern JS, Resnick LM, Clark S, Morris CD, Hatton DC, Metz JA, McMahon M, Holcomb S, Snyder GW, Pi-Sunyer FX. “Nutritional Management of Cardiovascular Risk Factors.” Archives of Internal Medicine 1997, 157 169-177.
Fujiwara K, Matsuoka A. “Continuous Administration Tests of Indigestible Dextrin II: Study on the effects of the improvement of fat metabolism in patients with non-insulin-dependent diabetes mellitus.” Japanese Journal of Clinical Nutrition, 1993, 83 (3) 301-305.
Matsuoka A, Saito M, Nagano S. “Continuous Administration Tests of Indigestible Dextrin I: Study on the effects of the improvement of fat metabolism in healthy volunteers.” Journal of the Japanese Diabetes Society,1992, 80 (2) 167-172.
Nomura M, Nakajima Y, Abe H. “Effects of Long-term Administration of Indigestible Dextrin as Soluble Dietary Fiber on Lipid and Glucose Metabolism.” Journal of Japan Society of Nutrition Food and Sciences, 1992 , 45 , 21-25.
Weight Management and Visceral Fat
Ye Z, Arumugam V, Haugabrooks E, Williamson P, Hendrich S. “Soluble dietary fiber (Fibersol-2) decreased hunger and increased satiety hormones in humans when ingested with a meal.” Nutrition Research. 2015 May;35(5):393-400.
Hendrich S, Ye Z, Arumugam V, Haugabrooks E, Williamson-Hughes P. “Fibersol-2 increases subjective and biochemical measures of satiety when ingested with a meal.” FASEB Journal. April 2010;24 (Meeting Abstract Supplement) 230.8.
Yamamoto T, Yamamoto K, Fukuhara Y, Fukui T, Kishimoto Y, Okuma K, Matsuoka Y, Isozaki K, Nagao K, Yamamoto T, Tokunaga K. “Effect of Indigestible Dextrin on Visceral Fat Accumulation” Journal of Japanese Society for the Study of Obesity, 2007, 13, 34-41.
Goda T, Kajiya Y, Suruga K, Tagami H, Livesey G, Kajiya Y, Suruga K, Tagami H, Livesey G. “Availability, fermentability, and energy value of resistant maltodextrin: modeling of short-term indirect calorimetric measurements in healthy adults.” American Journal of Clinical Nutrition, 2006, 83, 1321-1330.
Kishimoto Y, Wakabayashi S, Tokunaga K. “Effects of Long-term Administration of Indigestible Dextrin on Visceral Fat Accumulation.” Journal of Japanese Association for Dietary Fiber Research, 2000, 4 (2), 59-65.
Oku T, Nakamura S. “Evaluation of the relative available energy of several dietary fiber preparations using breath hydrogen evolution in healthy humans.” Journal of Nutritional Science and Vitaminology, 2014, 60, 246-254.
Kumashiro C, Kishimoto Y, Miyazato S, Hashimoto M, Yoshimura C and Nonomura M. “Evaluation of effectiveness of indigestible dextrin on female university students suspected to have anemia.” The Journal of Japan Mibyou System Association, Vol. 16 (2), 2010, 404-406.
Miyazato S, Nakagawa C, Kishimoto Y, Tagami H, Hara H. “Promotive effects of resistant maltodextrin on apparent absorption of calcium, magnesium, iron and zinc in rats.” European Journal of Nutrition, 2010, 49, 165-171.
Kajimoto O, Yoshimura C, Morimoto F, Henmi M, Ohki K, Takahashi T, Takeuchi H. “Safety of a long-term intake of a tea beverage containing indigestible dextrin.” Journal of Nutritional Food, 2001, 4 (2), 19-26.
Okuma K, Matsuda I. “Production of Indigestible Dextrin from Pyrodextrin.” Journal of Applied Glycoscience, 2003, 50, 389-394.
Okuma K, Matsuda I, Katta Y, Hanno Y. “Pyrolysis of Starch and Its Digestibility by Enzymes - Characterization of Indigestible Dextrin.” Journal of the Japanese Society of Starch, 1990, 37, 107-114.
Okuma K, Matsuda I. “Indigestible Fractions of Starch Hydrolysates and Their Determination Method.” Journal of Applied Glycoscience, 2002, 49 (4), 479-485.
Ohkuma K, Wakabayashi S. “Fibersol-2: a soluble, non-digestible, starch-derived dietary fiber,” in Advanced Dietary Fibre Technology, B. V. McCleary and L. Prosky, Eds., pp. 509–523, Iowa State University Press, Blackwell Science, Ames, Iowa, USA, 2001.
Okuma K, Wakabayashi S. “Fibersol-2: a Soluble, Non-digestible, Starch-derived Dietary Fibre.” Advanced Dietary Fibre Technology, B.V. McCleary & L. Prosky (Eds), Blackwell Science, Oxford, UK, 2001, pp 509-523.