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5-LOXINA® Shown to Reduce Pain and Stiffness in Osteoarthritis Sufferers

5-LOXIN®, an enriched extract of the Boswellia serrata herb, may improve the symptoms of osteoarthritis (OA) according to newly released research. This could be good news for the nearly 21 million people in the US that are currently affected by OA.

5-LOXIN® is an extract of boswellia serrata with 30% more AKBA, the nutritional acid that exhibits potential anti-inflammatory properties.

Researchers from UC Davis conducted a double-blind placebo controlled study of 70 individuals suffering from OA of the knee. Individuals were given a daily dose of either a placebo, 100mg of 5-LOXIN® or 250mg of 5-LOXIN®.

Each patient was evaluated for pain and physical function at the start of the trial and 7, 30, 60 and 90 days afterwards. At the beginning and at the end of the study, the researchers drew synovial fluid from each individual's knee to measure the amounts of MMP-3, an enzyme known to degrade cartilage.

Results were published in the journal Arthritis Research and Therapy on July 30, 2008.

Researchers found that both the 100mg and 250mg groups had statistically significant improvements in pain scores, physical function and in reductions of MMP-3 in synovial fluid.

Compared with the placebo group, the 100mg group had a 48.8% improvement in a visual pain assessment, 23.8% improvement in a functionality test, 39.6% improvement in pain scores and a 42.5% improvement in stiffness.

The 250mg group had improvements of 65.9%, 31.3%, 52.5% and 62.2% respectively on the same tests.

Furthermore, compared with the placebo group, the 100mg and 250mg groups had respective reductions of 31.4% and 46.4% in MMP-3 concentrations in their synovial fluid after 90 days.

This research adds to the growing amount of evidence that 5-LOXIN® has benefits for individuals suffering from arthritis symptoms. In 2007, India's Ministry of Science & Technology awarded the developer of 5-LOXIN® the prestigious National Award for Outstanding Achievement.

You can find 5-LOXIN® in NatureCity's advanced joint and muscle product, Alotin HA. NatureCity clients have been benefiting from this novel botanical ingredient for almost two years and this study helps show why.

Source: Arthritis Research and Therapy
July 30, 2008; 10:R85
A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee
Authors: Krishanu Sengupta, Krishnaraju V Alluri, Andey Rama Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey and Siba P Raychaudhuri
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