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A Multi-Enzyme Blend May Help Ease Indigestion

Dyspepsia is most commonly known as indigestion and it affects approximately 25% of all Americans. A recent study suggests a non-animal sourced enzyme blend may be safe and effective for people with dyspepsia.


Participants in the study included 40 people who took either 50 mg of a multi-enzyme complex or a placebo daily for 60 days. The complex included alpha-amylase, protease, cellulase, lactase, as well as lipase that digest carbohydrates, complex proteins, cellulosic fibers, lactose, and fats. Effectiveness of the complex was measured using the Short-Form Leeds Dyspepsia Questionnaire, the Nepean Dyspepsia Index-Short Form, the Visual Analog Scale, the Clinical Global Impression Severity Rating Scale, and the Glasgow Dyspepsia Severity Score. Scores were measured at baseline and follow-up visits on day 15, 30, and 60.


Supplementation resulted in significant changes in all the scores. In particular, the researchers noted significant improvements in epigastric pain and discomfort, postprandial distention, indigestion, heartburn, nausea, fullness, early satiety, bloating, belching after meals, and vomiting in the supplement group. No adverse events were reported. No similar improvements were seen in the control group.


Researchers from the Sami-Sabinsa Group led the study. It was published online ahead of print on August 29, 2018, in the Journal of Medicinal Food.

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