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A Supplement Containing Multivitamins and Ginseng May Help Improve Mood

Stress can play in role in increasing the risk of headaches, high blood pressure, heart problems, diabetes, skin conditions, depression, and anxiety. A new study has found that a supplement containing multivitamins, minerals, and ginseng may help improve mood and reduce blood markers of stress.

The researchers recruited 84 adults who reported at least one stress-related problem, such as sleep disturbances, depression, anxiety, and fatigue. Half were given 2 capsules daily for 180 days of the supplement that contained 833 IU of vitamin A, as beta carotene, 0.75 mg of vitamin B6, 3.5 μg of vitamin B12, 25 mg of vitamin C, 400 IU of vitamin D3, 11 IU of vitamin E, 50 mg of calcium chloride, 3.5 mg of iron sulfate, 20 mg of magnesium gluconate, 5 mg of zinc chloride, 12.5 μg of sodium selenate, and 100 mg of ginseng powder. The other half received a placebo.

Questionnaires were administered at baseline, 90 days, and 180 days to evaluate psychological symptoms including fatigue, mental stress, sleep disturbance, anxiety, depression, mood changes, self-confidence, and motivation. Blood was drawn at baseline, 90 days, and 180 days to measure levels of stress related hormones, klotho protein, inflammation markers, and neurotransmitters.

Participants in the supplement group saw significant reductions in scores of psychological symptoms at day 90 and day 180. The reductions were seen in fatigue, confidence, sleep disturbances, anxiety, depression, stress, future fearness, lack of motivation, and libido.

They also saw a 71.3% increase in vitamin D levels, a 45.03% increase in neurotransmitter levels, and a 500% increase in levels of klotho protein compared to the placebo group. Klotho protein has been associated with healthier aging. In addition, participants in the supplement group saw reductions in stress related hormones and inflammation markers.

The study was conducted by researchers from Trivedi Science Research Laboratory. It was published online ahead of print on August 11, 2022 in the journal Frontiers in Psychiatry.

A probiotic was found to help stress and gut health in a previous article.

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