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Aged Garlic Extract May Help Lower Inflammation in People With Obesity

People with obesity tend to have higher levels of inflammation, which can lead to other health problems including type 2 diabetes and cardiovascular disease. A recent study suggests that aged garlic extract may help reduce inflammatory markers in obese adults.


Participants in the study included 51 healthy adults with obesity who had a mean age of 45.6 years and a mean BMI of 36.1. The group was matched by BMI and then randomized into the supplement group or placebo group. The supplement group was given an aged garlic supplement in the form of three pills for a total of 3.6 g of aged garlic extract and the other half was given a placebo. The participants took three capsules with food twice daily for six weeks while they followed their usual dietary and exercise routines.


The researchers measured blood lipid and inflammatory markers at baseline and again at the end of the study. They also isolated peripheral blood mononuclear cells from whole blood and used that to detect changes in immune cell populations, as well as levels of cytokine secretion.


At the conclusion of the study, the researchers noted significantly lower levels of the inflammatory markers serum IL-6 and TNF-alpha in the aged garlic extract group, when compared with the placebo group. They also noted modulated immune cell distribution in the aged garlic group.


Researchers from the University of Florida conducted the study. It was published online ahead of print on January 3, 2018, in Clinical Nutrition ESPEN.


Aged garlic extract is a concentrated form of organic garlic that is odorless and richer in antioxidants than fresh garlic.

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