Berberine and Silymarin Supplementation Linked With Improved Blood Lipid and Blood Sugar Levels
Berberine is an alkaloid that is found in several plants
including European barberry, goldenseal, and tree turmeric. Silymarin is an
active component of the milk thistle plant. A recent study has found that
supplementation with a combination of berberine and silymarin is associated
with improved blood lipid levels and fasting blood sugar levels.
Researchers from the universities of Bologna, L’Aquila, and
Palermo included five studies in their review. The studies included 497
participants, with durations ranging from three to twelve months. The doses of
berberine used in the studies were 500 or 1,000mg per day, and the doses of
silymarin were 105 or 210mg per day. All of the studies assessed changes in plasma
concentrations of total cholesterol, triglycerides, high-density lipoprotein
cholesterol, low-density lipoprotein cholesterol, and fasting plasma glucose.
The researchers found that supplementation with a combination of berberine
and silymarin was associated with a 25 mg/dl reduction in total cholesterol, a
28 mg/dl reduction in triglycerides, a 29 mg/dl reduction in LDL cholesterol,
and a 6 mg/dl increase in HDL cholesterol. It was also associated with an
average decrease of 7.5 mg/dl in blood glucose levels.
The study was published online ahead of print January 10, 2019 in
the journal Phytotherapy