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Combination of Probiotics and Lactoferrin May Improve Bacterial Vaginosis Symptoms, Reduce Recurrence

Bacterial vaginosis BV) is a common affliction in pre-menopausal women, characterized by itching and abnormal vaginal discharge. BV is characterized by a depletion of beneficial bacteria and recurrent infections are fairly common. A recent study suggests that a mix of probiotics and lactoferrin may help improve symptoms of bacterial vaginosis and decrease recurrence.


Participants in the study included 48 women with symptomatic bacterial vaginosis. All of the women were treated with 500 mg metronidazole twice daily for seven days. They were also randomly assigned to also take either a probiotic mixture plus lactoferrin (verum) or placebo, in the form of two capsules per day for five days followed by one capsule per day for 10 consecutive days.


The 10 consecutive day administration of the supplement or placebo was repeated monthly during the six months of follow-up, starting the first day of menstrual cycle. This is because menstrual blood increases the vaginal pH and contributes to an increased risk of recurrences.


At the conclusion of the study, the researchers noted that symptoms including vaginal discharge and itching and Nugent score (which is used to diagnose BV) were significantly improved in theprobiotics/lactoferrin group. The BV recurrence rate was significantly reduced by the probiotic-lactoferrin combination, when compared with the placebo.


Researchers from Giellepi S.p.A. Health Science in Italy led the study It was published online ahead of print on December 10, 2018, in Beneficial Microbes.

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