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CoQ10 plus NAD May Lower Heart Rate, Reduce Fatigue in People With Chronic Fatigue

Chronic Fatigue Syndrome is a complex condition, characterized by severe disabling fatigue with no known cause, no established diagnostic tests, and no universally effective treatment. According to the CDC, as many as 1 million Americans suffer from chronic fatigue syndrome. A recent study suggests that supplementation with CoQ10 plus nicotinamide adenine dinucleotide (NAD) for eight weeks is safe for consumers and may reduce max heart rate and reduce fatigue in people with chronic fatigue syndrome.


Participants in the study included 80 women with chronic fatigue syndrome between the ages of 18 and 65. Over the course of eight weeks, they were given either CoQ10 and NAD — containing 50 mg CoQ10, 5 mg NAD, 10 mg phosphatidylerine, and 40 mg of vitamin C — or a placebo. They were all instructed to avoid any other supplements containing CoQ10, NAD, phosphatidylserine, and vitamin C during the study period.


The participants self-reported changes in fatigue, pain, and sleep at the four and eight week points via questionnaires. Researchers evaluated max heart rate functional response with an incremental cycle ergometer test at the beginning and end of the study.


After examining the data, the researchers found that the supplement group had a greater maximum heart rate reduction after cycling in week eight compared to the placebo group. The supplement group also had less perceived fatigue than the placebo group, however there was no statistically significant difference for pain perception or sleep disruption between the two groups. No adverse side effects from the supplements were noted.


Researchers from the Autònoma University of Barcelona led the study. It was published in the August 2016 issue of Clinical Nutrition.


CoQ10 is a powerful antioxidant that fuels the pumping of blood to and from the heart, and protects cells from being damaged and destroyed. Previous studies have linked CoQ10 with improved cognitive health and reversing the effects of aging.


After the age of 20 our bodies become less capable of naturally producing CoQ10. If you want to increase your CoQ10 intake, try adding oily fish, organ meats such as liver and hearts, and whole grains to your diet. You might also consider a high quality, high potency supplement. Be sure to choose a supplement that is made with ubiquinol rather than ubiquinone.


Nicotinamide adenine dinucleotide is a coenzyme that enables the transfer of energy from the foods we eat to our cells. NAD levels naturally decline as we age.

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