Phytosomal Curcumin and Piperine May Help Improve Health Parameters of Obese People
Obesity increases the risk of heart disease, high blood pressure, diabetes, metabolic syndrome, osteoarthritis, and gout. A new study suggests that supplementation with phytosomal curcumin and piperine may help improve insulin resistance, blood pressure, triglycerides, and fatty liver index in obese people.
Eighty obese people between the ages of 18 and 75 participated in the study. All of them had fasting plasma glucose levels 100 and 125 mg/dL (normal fasting plasma glucose levels are between 70 and 100 mg/dL). Participants took either a supplement containing 200 mg of phytosomal curcumin and 8 mg of piperine or a placebo daily for 8 weeks.
Blood samples were taken at baseline and at the end of the study. The researchers evaluated total cholesterol, high-density lipoprotein-cholesterol, triglycerides, LDL-Cholesterol, serum cortisol, fasting plasma insulin, fatty liver index, and fasting plasma glucose. All participants were also given standard diet advice and encouraged to increase physical activity.
Participants in the supplement group showed statistically significant improvements in fasting plasma glucose, fasting plasma insulin, and serum cortisol levels after 28 days. After 56 days, participants in the supplement group showed significant improvements in body mass index, waist circumference, and systolic blood pressure, compared to baseline. In addition, they had significant improvements in fasting plasma insulin, triglyceride levels, and fatty liver index compared to the placebo group.
The study was conducted by researchers from the University of Bologna and Mashhad University of Medical Sciences. It was published online ahead of print on February 22, 2019 in the European Journal of Nutrition.