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Curcumin Fenugreek Combo Associated with Improved Cardiovascular Health

Homocysteine is an amino acid present in the blood that is a biomarker of cardiovascular health. A study conducted by researchers at the University of Kentucky suggests that a combination of curcumin and fenugreek may help lower homocysteine levels in obese young men.

Twenty-two young, obese men participated in the study. All of them were otherwise healthy, with no hypertension, previous myocardial infarction, diabetes, or hyperglycemia. Half of the participants consumed 500 mg of a supplement containing 193 mg of curcuminoids infused into 60% soluble fiber from fenugreek.  The other half took a placebo. The supplementation period lasted 12 weeks.

Blood samples and endothelial function measures were acquired at baseline and the end of the study. The blood samples were analyzed for cardiovascular health related blood biomarkers. Central (aortic) blood pressure was monitored at weeks 0, 4, 8, and 12.

By the end of the study, homocysteine levels in the supplement group decreased from 12.22 to 8.62. In comparison, they increased in the placebo group, from 9.45 to 11.84. HDL levels were also higher in the supplement group compared to the placebo group. No significant changes were seen in glucose, insulin, leptin, or adiponectin levels, or in endothelial function and central blood pressure.

The study was published online ahead of print on January 11, 2019, in the journal Nutrition.

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