Curcumin Shown to Have Liver Health Properties
Non-alcoholic fatty liver disease (NAFLD) is characterized by an abnormal accumulation of fat in the liver that can lead to liver damage. A recent study has found that supplementation with nanocurcumin may help decrease fat accumulation in the liver and improve HDL cholesterol levels in obese people with NAFLD.
84 obese people with NAFLD participated in the study. Participants took 40 mg of nanocurcumin twice daily, once at breakfast and once at dinner, or a placebo for 3 months. The researchers measured weight, waist circumference, liver size, accumulation of fat in the liver, and blood biomarkers at the beginning and end of the study.
At the end of the study, the researchers found that participants in the nanocurcumin group had significantly increased levels of HDL cholesterol and nesfatin, a neuropeptide that plays a role in the regulation of fat storage and hunger. The nanocurcumin group also had decreases in fatty liver degree, several biomarkers of inflammation in the liver, and waist circumference. No changes were seen in the placebo group.
The supplement used in the study is nanocurcumin, which was developed to increase the bioavailability of the curcumin. The bioavailability of nanocurcumin is up to 80-95%, which brings effective treatment 40 times higher than regular curcumin.
The study was conducted by researchers from Tehran Universithy of Medical Sciences, Alborz University of Medical Sciences, and the Baqiyatallah University of Medical Sciences. It was published online ahead of print on January 28, 2019 in the journal Nutrition and Metabolism.