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Delta-Tocotrienol Supplementation May Help Improve Liver Health

Delta-tocotrienols are one of the four types of tocotrienols found in Vitamin E. Previous research has found that delta-tocotrienols have the highest antioxidant property of the vitamin E family. A recent study suggests that supplementation with delta tocotrienols sourced from annatto may help improve biochemical markers of liver health in people with non-alcoholic fatty liver disease (NAFLD).

Seventy-one people with NAFLD participated in the study. Participants received 300 mg of delta-tocotrienols or a placebo twice daily for 24 weeks. All participants were also assigned to a low-fat diet. The researchers measured liver enzyme levels, markers of oxidative stress, the fatty liver index, and HOMA-IR scores (a measure of insulin resistance) at baseline and at the end of the study period. Weight, BMI, and waist circumference were also measured.

Participants in the tocotrienol group saw an average 20% decrease in liver enzymes. Elevated liver enzymes often indicate inflammation or damage to cells in the liver. They also saw a 15% decrease in the fatty liver index, which includes measures of weight, BMI, waist circumference, gamma-glutamyl transferase, and triglycerides. In addition, HOMA-IR scores were reduced by 15% in the tocotrienol group.

The study was conducted by researchers from the National University of Medical Sciences, Pakistan. It was published online ahead of print on June 23, 2020 in thejournal Complementary Therapies in Medicine.

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