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Drink Containing Omega-3s and Botanicals May Help Slow Advancement of Cognitive Decline

Mild cognitive impairment is the intermediate stage between the normal cognitive decline seen with aging and the more serious decline of dementia. A recent pilot study suggests that a drink containing a mix of omega-3s and mixed botanicals may have significant immune and biochemical effects on people with mild cognitive impairment.


Participants in the study included 12 people with mild cognitive impairment, two people with pre-mild cognitive impairment, and seven people with Alzheimer’s disease. They were given the 2000 mg drink containing high levels of DHA and EPA, resveratrol, vitamin D3 and other vitamins and antioxidants for between four and 17 months.


The researchers found that the people with mild cognitive impairment and pre-mild cognitive impairment had an increase in beta amyloid clearance from 530 to 1306 mean florescence intensity units. This was measured by looking at the destruction of beta amyloid by white blood cells called monocytes. Beta amyloid plaque buildup in the brain is associated with the progression of Alzheimer’s disease.


The researchers also found the anti-inflammatory resolvin RvD1 increased in the macrophages in 80% of the patients with mild cognitive impairment and pre- mild cognitive impairment. Macrophages are white blood cells that engulf and digest cellular debris, foreign substances, microbes, and cancer cells. Resolvin RvD1 has been shown to help clear out beta amyloid in labs.


The researchers also believe that supplementation may have helped stabilize the cognitive status of the participants with mild cognitive impairment and pre- mild cognitive impairment. They did not show any significant changes in their minimental state examinations, as would be expected over a long period of time from people suffering from mild cognitive impairment.


Researchers from UCLA conducted the study. It was published online ahead of print on March 24, 2015, in The FASEB Journal.


Omega-3s have been linked to a number of health benefits, including alleviating arthritis pain, better moods, improved joint mobility, helping with age related macular degeneration, and aiding your immune system.


Because omega-3 fatty-acids are not found naturally in the human body, it is especially important to make sure that they are a part of your daily diet. Oily, dark fish such as tuna and salmon are high in DHA and EPA omega-3s.

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