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Probiotic May Improve Some Metabolic Risk Factors In Obese or Overweight People


People with metabolic syndrome have an increased risk of
developing heart disease, type 2 diabetes, and stroke, A new study suggests
that supplementation with the gut bacteria Akkermansia muciniphila may
help improve insulin sensitivity and cholesterol in obese or overweight people
with some symptoms of metabolic syndrome.





Participants in the study included 32 overweight or obese adults
who were insulin resistant. Half of the participants took 10 billion CFU of
live Akkermansia muciniphila, 10 billion CFU of pasteurized Akkermansia
muciniphila
,or a placebo daily for three months. The researchers measured
insulin resistance, insulin sensitivity, circulating lipids, visceral
adiposity, and BMI at baseline and at the end of the study.





Particpants who took the live or pasteurized Akkermansia
muciniphila
had improved insulin sensitivity and reduced concentrations of
insulin in the blood at the end of the study. 
They also had decreases in total plasma cholesterol and inflammation
biomarkers. In addition, they lost an average of 5 pounds, but the weight loss
was not statistically significant.





The study was conducted by researchers from the Catholic
University of Louvain, Belgium. It was published on July 1, 2019 in the journal
Nature Medicine.


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