Higher Dose of Probiotics Associated With Higher Colonization of Probiotics
Probiotics need to have the ability to survive in the
gastrointestinal tract in order to confer health benefits. A new study has
found that consuming higher doses of a multispecies probiotic formulation is
associated with greater survival of probiotics.
For this study, 40 healthy adults between the ages of 18 and 60
were randomly divided into two equal groups. One group took a multistrain
probiotic formulation containing 7 billion CFU daily for two weeks. The other group took a multistrain probiotic
formulation containing 70 billion CFU. Participants were monitored for a follow
up period of two weeks. The researchers collected 19 fecal samples in total.
The researchers found that probiotic recovery in a fecal sample
happened earlier in the high dose group compared to the low dose group. Fecal
samples collected on day 14 from the high dose group showed that all four
probiotic strains had survived the gastrointestinal tract. In the low dose
group, all four probiotic strains survived in only 65% of the group. In
addition, the overall number of viable probiotic cells collected on day 14 was
significantly higher in the high dose group compared to the low dose group.
The study was conducted by researchers from the University of
Milan. It was published on January 29, 2019 in the journal Nutrients.