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HMB plus Probiotic BC30 May Help Combat Inflammation and Boost Muscle Production

HMB (beta-hydorxy-beta-methylbutyrate) is a metabolite of leucine and previous studies suggest that it may help muscle synthesis and prevent muscle fiber breakdown. A recent study suggests that combining HMB with the probiotic BC30 may enhance the muscle and anti-inflammatory properties of HMB.


Participants in the study included 26 Israeli solders that were taking part in 40 days of intense military training. They were given one of three interventions: 3 grams of a combination of HMB and calcium plus one billion CFUs of BC30; 3 grams of HMB and calcium alone; or no intervention, which acted as the control.


At the conclusion of the study, the researchers noted significant increases in IL-1beta, IL-2, IL-6, CX3CL1, and TNF-alpha — all markers of inflammation — in the control group. No increases were seen in either of the supplement groups. They also noted increases of the anti-inflammatory marker IL-10 in the combination CaHMB and BC30 group, but not in the control group or the HMB alone group. Additionally, they noted greater protection of muscle integrity in the calcium, HMB, and BC30 group, when compared with the calcium and HMB alone. 


There were no changes in muscle damage in any of the groups.


Researchers from University of Central Florida led the study. It was published on April 13, 2017, in the Journal of Applied Physiology.


HMB is a metabolite of the amino acid leucine. It has previously been linked to bolstering muscle synthesis and preventing muscle fiber breakdown. Recent studies have found that HMB may reduce the risk of sarcopenia and help support physical strength and functionality.


BC30 is a probiotic that has been linked in previous studies with improving workout performance. It is best to take it in supplement form.

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