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Hyaluronan May Reduce Appearance of Wrinkles

Hyaluronan has moisturizing properties and high water retention capacity for skin. A recent study suggests that oral supplementation of hyaluronan may improve the appearance of skin and reduce wrinkles.


Participants in the study included 60 Japanese men and women between the ages of 22 and 59 who presented with crows feet wrinkles. They were given either a placebo, hyaluronan with a molecular weight of 2k, or hyaluronan with a molecular weight of 300k daily for 12 weeks. The hyaluronan groups received doses of 120 mg per day. Skin wrinkles were evaluated by image analysis of skin wrinkle replicas, and skin condition was evaluated using a questionnaire survey.


At the conclusion of the 12-week supplementation period, both of the hyaluronan groups had improvements in grooves in the skin to volume ratio, wrinkle area ratio, and wrinkle volume ratio, when compared with the placebo and with baseline assessments. However, only the 300k group saw a significantly diminished appearance of wrinkles, when compared with the placebo.


All of the groups had improvements in luster, but the hyaluronan groups had greater increases.


Researchers from Toho University Ohashi Medical Center conducted the study. It was published on July 18, 2017, in Clinical, Cosmetic and Investigational Dermatology.


Hyaluronan is found naturally throughout the body. Previous studies suggest that it may help provide relief for dry eyes and help lubricate the joints, similar to the way that oil lubricates an engine.


Some foods that are good sources of hyaluronan are fish oil, vitamin C-rich fruits, and foods rich in magnesium such as broccoli, kale, avocados and carrots. You can also take a high quality supplement to increase your hyaluronan intake.

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