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Indian Gooseberry May Help Reduce Platelet Aggregation

Diabetics are at a high risk for increased platelet aggregation, which can result in the formation of blood clots. A recent study has found that an extract from Indian gooseberry could reduce platelet aggregation by more than 36% in people with type-2 diabetes.

Participants in the study included 10 adults with type-2 diabetes, all of whom underwent a single dose and a multiple dose trial. For the single dose trial, they were given either 500 mg of Indian gooseberry, 75 mg of Clopidogrel (an anti-clotting medication) or 75 mg Ecosprin (enteric-coated aspirin).

Following the single-dose phase, the participants underwent a washout period and proceeded to the multiple dose phase. During this phase, they were given either 500 mg of Indian gooseberry with 75 mg of Clopidogrel or 500 mg of Indian gooseberry with 75 mg of Ecosprin.

In both phases, the researchers measured platelet aggregation and bleeding and clotting times at baseline and four hours after treatment.

The researchers noted that the Indian gooseberry on its own reduced platelet aggregation by 36%, Clopidogrel reduced it by 51% and Ecosprin reduced it by 51%. When Indian gooseberry was taken in combination with each of the two drugs, those numbers rose to 53% for the Clopidogrel combo and 56% for the Ecosprin combo.

One area of concern for the researchers is that fact that greater than 50% inhibition of platelet aggregation is correlated with bleeding events. Indian gooseberry taken alone inhibited platelet aggregation by 27% and 36% for single and multiple doses respectively. Inhibition for Clopidrogel was 47% and 50, and for Ecosprin it was 46% and 51%.

Researchers from Nizam’s Institute of Medical Sciences in India conducted the study. It was published online ahead of print on November 28, 2013, in Phytomedicine.

Previous studies have shown that Indian gooseberry may help reduce pain and swelling in the pancreas, help with upset stomach, eye problems, joint pain, diarrhea, dysentery, obesity, and inflammation. It has traditionally been used in Ayurvedic medicine and can be found in supplement form.

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