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L-citrulline Plus Glutathione May Boost Nitrite Levels in Blood and Help Improve Blood Flow

Initial studies have found that L-citrulline may help increase levels of nitrite and nitrogen oxide levels, which are important for keeping blood thin and flowing. A recent study suggests that supplementation with L-citrulline in combination with glutathione may help increase nitrite and nitric oxide levels in the blood and improve blood flow better than L-citrulline alone.


Participants in the study included 60 resistance-trained men with an average age of 22. Over the course of seven days they were give either 2 grams of L-citrulline alone, 1 gram of glutathione alone, 2 grams of L-citrulline plus 200 mg of glutathione, or a placebo.


At the conclusion of the study, the researchers found that the combination group had significantly higher nitrite and nitrogen oxide levels 30 minutes after exercise when compared with the placebo group.


Participants in the combination group also had a non-significant increase in cyclic guanosine monophosphate synthesis. Cyclic guanosine monophosphate synthesis relaxes smooth muscle tissues. Relaxation of vascular smooth muscles leads to vasodilation and increased blood flow.


Researchers from Baylor University conducted the study. It was published on June 10, 2015, in the Journal of the International Society of Sports Nutrition.


Recent studies suggest that L-citrulline has antioxidant properties that could be useful in combating hypertension, heart failure, and atherosclerosis. In addition to supplements, L-citrulluine is also found in watermelons, other melons, squash, cucumbers, and pumpkins.


Previous research has shown that glutathione neutralizes free radicals, enhances the immune system and detoxifies the liver. It also protects cells from bacteria, viruses and toxins.


Foods rich in glutathione include asparagus, spinach, avocado, squash, melons, grapefruit and peaches. It is also found in meat sources of protein, whole wheat, oatmeal, bran flakes, popcorn, and whey protein. While eating a balanced diet is the best way to increase your glutathione intake, this study shows that taking oral glutathione supplements is also a viable option.

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