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Moderate Calorie Restricted Diet Found To Reduce Risk Of Cardiovascular Disease


Previous studies have linked being overweight with an increase in several cardiometabolic risk factors and an increased risk of a cardiovascular event. A recent study suggests that a long-term calorie restricted diet may improve cardiometabolic risk factors and reduce the risk of cardiovascular disease.





Two hundred and eighteen healthy adults between the ages of 21 and 50 with a BMI between 22.0 and 27.9 kg/m2participated in the study. Half of them were assigned a 25% calorie restricted diet and half a control diet for 2 years. Researchers evaluated systolic, diastolic, and mean blood pressure, plasma lipids, high-sensitivity C-reactive protein, metabolic syndrome score, and glucose homoeostasis measures of fasting insulin, glucose, insulin resistance, and 2-h glucose, area-under-the curve for glucose, and insulin from an oral glucose tolerance test at baseline and throughout the study.





After 2 years, participants in the calorie restricted group saw a significant reduction in all measured cardiometabolic risk factors, including LDL cholesterol, total cholesterol to HDL cholesterol ratio, and systolic and diastolic blood pressure. They also saw significant improvement in C-reactive protein, insulin sensitivity index, and metabolic syndrome score compared to the control group.





Calorie restricted diet participants also lost an average of 16 pounds, compared to an increase of 3 pounds in the control group. The researchers calculated that the risk of heart attack was reduced by a factor of 13 in the calorie restricted diet group.





The study was conducted by researchers from Duke University. It was published on July 11, 2019 in The Lancet Diabetes & Endocrinology.


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