New Study Uncovers Reason Lack of Sleep Increases Cardiovascular Disease Risk
Not getting enough sleep can negatively impact the body in a number of ways, including increasing the risk of cardiovascular disease, weakening the immune system, and increasing the risk of type 2 diabetes. A new study claims to have uncovered the reason lack of sleep increases the risk of cardiovascular disease.
Twenty-four healthy adults between the ages of 44 and 62 participated in the study. The participants filled out questionnaires regarding their sleep habits. Half of the participants slept more than 7 hours per night, and half of them slept less than 7 hours per night.
The researchers took blood samples to measure the circulation of several MicroRNAs; miR?34a, miR-92a, miR-125a, miR-126, miR-145, miR-146a, and miR-150. MicroRNAs play a key role in regulating vascular health, and circulating levels are used as biomarkers of cardiovascular function, inflammation, and disease.
The researchers found that circulating levels of miR-125a, miR-126, and miR-146a were significantly lower in the group that got less sleep, compared to the group that got more sleep. Specifically, they were 60%, 40%, and 60% lower respectively. The researchers believe that dysregulation of these microRNAs may contribute to increased inflammation and endothelial dysfunction.
The study was conducted by researchers from the University of Colorado Boulder. It was published online ahead of print on November 22, 2018 in the journal Experimental Physiology.