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Omega-3s May Help Combat Chronic Inflammation in Obese Women

Obesity is characterized by carrying a lot of excess body weight, to the point where it has a negative affect on your health. A recent study suggests that taking omega-3 supplements in addition to controlling caloric intake may help fight the chronic inflammation that typically accompanies obesity.


Participants in the study included 59 moderately obese women with an average age of 46.6 who were given either omega-3 supplements containing 1,290 mg of DHA and 270-450 mg of EPA or a placebo daily for three months. All of the participants also followed a calorie-controlled diet during the study period.


At the conclusion of the study, the researchers noted significant body weight, fat mass, and BMI reductions in both the placebo and the supplement group. However, only the omega-3 group had significant increases in EPA and DHA, as well as decreases in inflammatory markers, including E-selectin, monocyte chemoattractant protein 1, vascular cell adhesion molecule 1, and C-reactive protein.


The supplement group also had increases in specialized pro-resolving mediators, which are cell signalling molecules that are formed by the metabolism of polyunsaturated fatty acids. They also had an increase in specialized pro-resolving mediators that are associated with up-regulated expression of the enzyme ALOX5, which helps with specialized pro-resolving mediators productions.


The researchers also noted effects on specific genetic pathways that are linked to catabolism of fatty acids in mitochondria, the synthesis of phospholipids, mitochondrial electron transport chain, and antioxidant enzymes.


Researchers from Jagiellonian University in Poland and the University of Southampton in the UK conducted the study. It was published in the November 2016 issue of Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.


Omega-3s have been linked to a number of health benefits, including improved mood, improved joint mobility, reducing the risk of age related macular degeneration, and aiding your immune system.


Because omega-3 fatty-acids are not found naturally in the human body, it is especially important to make sure that they are a part of your daily diet. Oily, dark fish such as tuna and salmon are high in omega-3s. For people who don’t like fish, consider taking a daily high quality non-fish supplement that has been tested for purity and potency.

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