Palmitoylethanolamide (PEA) May Help Improve Knee Osteoarthritis Symptoms
(PEA) is an endogenous fatty acid amide that acts as a repair
mechanism for inflammation. According to a new study, PEA may help
reduce pain and other symptoms of knee osteoarthritis.
hundred eleven participants with mild to moderate knee osteoarthritis
participated in the study. They received 300 mg of PEA, 600 mg of
PEA, or a placebo daily for 8 weeks. The Western Ontario and McMaster
Universities Osteoarthritis Index (WOMAC) was used to assess pain,
stiffness, and function. The Depression Anxiety Stress Scale (DASS)
and the Perceived Stress Scale (PSS) were used to assess anxiety.
researchers found that both the 300 mg and 600 mg supplement groups
had significant reductions in the total WOMAC score, compared to the
placebo group. They also had significant reductions in the WOMAC pain
score, the WOMAC stiffness score, and anxiety.
The study was conducted by researchers from Sydney Medical School and the University of Hong Kong. It was published online ahead of print on March 29, 2019 in the journal Inflammopharmacology.