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Pomegranate Metabolite May Have Anti-Aging Benefit


As the body ages, it begins to lose its ability to clean up dysfunctional mitochondria, which can lead to the loss of skeletal muscle mass and the weakening of other tissues. A new study suggests that urolithin A (UA) may have an anti-aging benefit, due to its impact on mitochondrial and cellular health. 





Sixty elderly, sedentary, healthy people participated in the study. They received 250, 500, or 1,000 mg of UA derived from pomegranate or a placebo daily for 28 days. The researchers looked at cellular and mitochondrial biomarkers in the participants’ blood and muscle tissue to assess the effectiveness of UA.





The researchers found that supplementation with UA improved the functioning of mitochondria. This suggests that UA may help maintain healthy muscle function during aging, by reestablishing the cell’s ability to recycle defective mitochondria.





Urolithin A (UA) is a metabolite created by the transformation of ellagitannins by gut bacteria. Ellagitannins are found in pomegranate, strawberries, raspberries, and walnuts





The study was conducted by researchers from the Neurodegenerative Diseases Laboratory, Switzerland and the Laboratory for Integrative and Systems Physiology, Switzerland. It was published online ahead of print on June 14, 2019 in the journal Nature Metabolism.


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