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Probiotic Bacillus subtilis DE111 May Ease Constipation, Diarrhea

Both constipation and diarrhea are uncomfortable digestive issues that can have negative effects on a person’s daily life. A recent study suggests that taking a daily dose of the probiotic Bacillus subtilis DE111 may help improve constipation and/or diarrhea in healthy adults.


Participants in the study included 50 people with occasional constipation and/or diarrhea who were given either 1 billion CFU of Bacillus subtilis DE111 or a placebo daily for 105 days. The researchers scored participants’ stools based on the Bristol Stool Chart index and assessed supplement safety via blood markers.


At the end of the supplementation period, the researchers found that the Bacillus subtilis DE111 group improved on the Bristol Stool Chart index, while the placebo group did not show any changes. They also found that Bacillus subtilis DE111 was associated with a reduction in alternating constipation and diarrhea, when compared with the placebo.


The proportion of normal stools increased from 54% to 64% in the Bacillus subtilis DE111 group, while the proportion of normal stools decreased from 56% to 48% in the placebo group. In addition, male participants had an increased proportion of normal stools from 57% to 80%.


Researchers from Deerland Enzymes conducted the study. It was published on November 10, 2017, in the Journal of Probiotics & Health.


Bacillus subtilis DE111 is a strain of the probiotic Bacillus subtilis, which previous research suggests may help with supporting the normal immune reaction of intestinal cells, crowding out bacterial pathogens, and maintaining health gut flora. It can be taken in supplement form.

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