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Probiotic Combo May Help Improve Cardiometabolic Health in Diabetics

People with type 2 diabetes and metabolic syndrome exhibit the highest cardiovascular risk. A recent study suggests that a combination of eight probiotic strains may help improve cardiometabolic health in people with diabetes.


Participants in the study included 30 people with diabetes who were given either a multi-strain probiotic containing five billion CFUs or a placebo daily for six months. The probiotic strains included were Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, Lactococcus lactis W19, and L. lactis W58.


At the conclusion of the study, the probiotic group had a 38% reduction in glucose, a 38% reduction in insulin, and a 64% reduction in insulin resistance, when compared with baseline. They also had 48% improvements in triglycerides and 19% improvements in total cholesterol, as well as a 19% reduction in the ratio of total to HDL cholesterol.


In regards to inflammation, they noted a 67% reduction in TNF-alpha, a 77% reduction in interleukin, and a 53% reduction in C-reactive protein. In addition, they noted a 53% reduction in resistin and a 72% reduction in adiponectin.


Compared with the placebo, there was a 64.2% reduction in HOMA-IR. HOMA-IR is a measure of insulin resistance.


Researchers from University of Warwick led the study. It was published online ahead of print on August 17, 2018, in Clinical Nutrition.

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