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Probiotic Combo May Help Relieve Symptoms of Leaky Gut

Leaky gut occurs when toxic bacteria passes from the gut into the blood. A recent study suggests that spore-based probiotics may help combat chronic immune activation and inflammation caused by leaky gut.


Participants in the study included 28 people who appeared healthy, but were identified as responders by a screening for post-prandial dietary endotoxemia. Specifically, five hours after eating, their endotoxin concentrations increased by at least five times from pre-meal levels. High endotoxin levels after a meal is a characteristic of leaky gut.


Over the course of 30 days, the participants were given either a rice flour placebo or a supplement containing 4 billion cfus of Bacillus indicus (HU36), B. subtilis (HU58), B. coagulans, B. licheniformis, and B. clausii. The dietary endotoxemia test was repeated at the end of the study period. Dietary endotoxin and triglyceride levels were measured using an automated chemistry analyzer.


At the conclusion of the study, the supplement group had a 42% reduction in endotoxin levels and a 24% reduction in triglyceride levels. In comparison, the placebo group had a 36% increase in endotoxin levels and a 5% decrease in triglycerides.


In addition, several exploratory biomarkers of inflammation and immune activation were either significantly reduced or trended toward reduction.


Researchers from the University of North Texas conducted the study. It was published online ahead of print on August 15, 2017, in World Journal of Gastrointestinal Pathophysiology.


Bacillus indicus (HU36) is essential for synthesizing carotenoids. B. subtilis (HU58) has been found in previous studies to help with blood pressure, cholesterol, and circulation. B. coagulans has been found to help with digestion and absorption of nutrients. B. licheniformis is a spore bacteria that is associated with improved immune function and improved gut health. B. clausii is often recommended to patients who are taking antibiotics and looking to maintain levels of healthy bacteria.

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