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Probiotic May Help Improve Blood Sugar In Obese Adults

Obesity is thought to trigger changes to the body's metabolism, including increasing blood sugar levels. A recent study has found that supplementation with the probiotic Bifidobacterium longum APC1472 may help improve blood sugar levels in healthy overweight or obese adults.

Participants in the study included 124 adults with a BMI between 28 and 34.9 kg/m². They were given 10 billion CFUs of Bifidobacterium longum APC1472 or a placebo daily for 12 weeks. Plasma blood samples were taken at baseline, week 3, week 6, and week 12, and were used to measure cholesterol, triglycerides, glucose, insulin, cortison, and ghrelin levels. The researchers also measured BMI and waist-to-hip ratio.

Participants in the probiotic group saw a significant reduction in fasting glucose levels compared to the placebo group. They also saw decreases in the cortisol awakening response and increased active ghrelin. Cortisol the primary stress hormone that increases sugars (glucose) in the bloodstream, Obesity is associated with an impairment of the ghrelin system. No changes were seen in BMI or waist-to-hip ratio.

The study was conducted by researchers from University College Cork. It was published online ahead of print on December 18, 2020 in the journal EBioMedicine.

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