Probiotic Obtained From Elderly May Provide Anti-Oxidative and Gut Microbiota Benefits
Previous research has found that people who live to a very old age have high intestinal microbial diversity and high levels of beneficial probiotics. A recent study has found that supplementation with the probiotic strain Lactobacillus casei LTL1879 isolated from older adults may have a beneficial effect on oxidation and the gut microbiome.
Twenty adults between the ages of 20 and 35 participated in the study. They were given 2 grams of powdered Lactobacillus casei LTL1879 obtained from adults over the age of 100 or a placebo daily for 3 weeks. Oxidative markers, inflammatory markers, and gut microbiota composition were evaluated at baseline and at the end of the study period.
Participants in the probiotic group had significant reductions in oxidative stress and a 52.7% increase in total antioxidant capacity compared to the placebo group. They also saw an 8.1% increase in the anti-inflammatory cytokine IL-10 and a 32.38% decrease in the pro-inflammatory cytokine TNF-alpha.
Participants in the probiotic group also saw significant changes in gut microbiota. E. coli levels decreased by 33.5%, while levels of the beneficial bacterium Bifidobacterium and Lactobacillus increased by 27.3 and 44.3% respectively.
The study was conducted by researchers from Guangxi University. It was published online ahead of print on October 29, 2021 in the journal Nutrients.