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Probiotic Shown to Improve Fasting Blood Sugar and Insulin Levels In Diabetics


Previous studies have linked changes in the gut microbiota to the development of type 2 diabetes and obesity. A new study has found that supplementation with the probiotic Lactobacillus casei may help improve fasting blood sugar, insulin concentration and insulin resistance in people with diabetes.





Forty people with type 2 diabetes participated in the study. Half of them took a capsule daily containing 100 million CFU of Lactobacillus casei.  The other half took a placebo capsule containing maltodextrin. Anthropometric measurements, dietary intake questionnaires, and blood samples were collected at the beginning of the study. Participants were also assessed by an endocrinologist at the beginning and end of the study.





At the end of the study period, fasting blood sugar, insulin concentration, and insulin resistance had significantly decreased in the supplement group, compared to the placebo group. Participants in the supplement group also saw decreases in their glycated hemoglobin, although not to a significantly statistical level.





In addition, participants in the supplement group saw a significant increase in serum sirtuin1, which is a protein inversely associated with insulin resistance. They also saw a significant decrease in fetuin-A levels, a blood protein directly associated with insulin resistance.





The study was conducted by researchers from Tabriz University of Medical Sciences in Iran. It was published in the January 2019 issue of the Iranian Biomedical Journal.


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