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Study Finds Citrus Flavones and Olive Polyphenols Improve Markers of Heart Health

Citrus flavones and flavanones are compounds found in citrus fruit that have strong antioxidant properties. Polyphenols are phytochemicals that naturally occur in plants and have strong antioxidant and anti-inflammatory properties. According to a new study, supplementation with an extract containing grapefruit and bitter orange flavones and flavanones and olive polyphenols may help improve markers of heart health.

Participants in the study included 96 healthy adults with an average age of 57.5. They were given a capsule containing 250-300 mg of flavanone-glycosides, 175-200 mg of flavones, and 85-90 of olive polyphenols or a placebo twice daily for 8 weeks. The researchers measured flow-mediated dilation and blood pressure at baseline and at the end of the study period. Blood samples were taken and used to evaluate lipid levels and markers of inflammation.

The researchers found that participants in the supplement group saw an average 3% increase in flow-mediated dilation, compared to a 0.5% increase in the placebo group. They also saw significant improvements in diastolic blood pressure, total cholesterol, LDL cholesterol, and markers of inflammation. Total cholesterol levels decreased by 13.57 mg/dl, compared to an increase of 6.38 mg/dl in the placebo group. LDL and HDL cholesterol levels improved by -8.82 mg/dl and 1.65 mg/dl respectively, compared to increases in LDL and decreases in HDL in the placebo group.

The study was conducted by researchers from Universidad Católica San Antonio de Murcia. It was published online ahead of print on May 19, 2020 in the journal Nutrients.

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