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Study Finds Nitrosigine Increases Nitric Oxide Production


Nitric oxide is a compound in the body that causes blood vessels to widen and stimulates the release of certain hormones, such as insulin and human growth hormone. Previous studies have found that citrulline malate may help increase nitric oxide production. Now a new study suggests that Nitrosigine is as effective as citrulline malate in increasing nitric oxide production.





Participants included 22 healthy, normotensive, moderately active young adults. The participants took part in three interventions, each followed by a 7-day washout period. During the interventions they were given 1.5 g of Nitrosigine, 8 g of citrulline malate, or a placebo. Flow-mediated dilation was measured at baseline and 60 minutes after consuming the supplement.





The researchers found that both Nitrosigine and citrulline malate resulted in a greater change in flow-mediated dilation compared to the placebo. Flow-mediated dilation is the widening of an artery when blood flow increases in that artery. The primary cause is a release of nitric oxide by endothelial cells.





The study was conducted by researchers from the University of Arkansas. It was presented at the International Society of Sports Nutrition Annual Conference held the week of June 13, 2019.


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