Study Finds Supplement May Help Improve Muscle Strength and Cognition in Mature Adults
Glycine and N-acetylcysteine are amino acids that help produce the natural antioxidant glutathione. A new study has found that supplementation with glycine and N-acetylcysteine may help improve a number of age-associated defects and improve muscle strength and cognition in mature adults.
Participants in the study included 8 mature adults with an average age of 75 and 8 young adults with an average of 25. The mature adults were given 1.33 mmol/kg/day of glycline and 0.81 mmol/kg/day of N-acetylcysteine daily for 24 weeks. Researchers measured levels of red‐blood cell glutathione, mitochondrial fuel‐oxidation, plasma biomarkers of oxidative stress, inflammation, endothelial function, glucose, and insulin, gait‐speed, muscle strength, cognitive tests, glucose‐production, and muscle‐protein breakdown rates. Measurements for mature adults were taken at baseline, 12 weeks, 24 weeks, and 12 weeks after stopping supplementation. Measurements for young adults were taken at baseline.
The researchers found that all of the measurements were abnormal in the mature participants compared to the young participants. In mature participants, supplementation with glycine and N-acetylcysteine corrected red blood cell glutathione deficiency and oxidative stress and mitochondrial dysfunction. It also improved inflammation, endothelial dysfunction, insulin-resistance, cognition, muscle strength, gait-speed, and exercise capacity. These results declined 12 weeks aftger stopping supplementation.
The study was conducted by researchers from Baylor College of Medicine. It was published online ahead of print on March 27, 2021 in the journal Clinical and Translational Medicine.