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Supplementation with HMB and Vitamin D May Help Mature Adults Improve Muscle Strength

Beta-hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite that is generally utilized to promote muscle-building and increase physical activity. A recent study has found that supplementation with HMB and vitamin D may help improve muscle strength and physical functionality in mature adults.

Participants in the study included 117 healthy adults over the age of 60 with insufficient circulating levels of vitamin D. They were assigned to one of four interventions for 12 months:

  1. 2,000 IU of vitamin D and 3.0 grams of calcium HMB daily combined with moderate resistance exercise program;
  2. Placebo and moderate resistance exercise program;
  3. 2,000 IU of vitamin D and 3.0 grams of calcium HMB daily and no exercise;
  4. Placebo and no exercise.

The moderate resistance exercise program consisted of 60 minutes of supervised resistance training three times per week. Body composition, strength, and physical functionality were evaluated every three months.

Participants in the supplement with no exercise group saw greater improvements in physical functionality and muscle strength compared to participants in the placebo and no exercise group. Participants in the supplement with exercise group saw only minimal improvements compared to the supplement with no exercise group.

The study was conducted by researchers from Iowa State University. It was published online ahead of print on August 28, 2020 in The Journals of Gerontology.

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