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Study Suggests Not All Arginine Supplements Are Equally Effective

Arginine is used in sports nutrition to increase blood flow. However, all arginine supplements may not be equal. A recent study suggests that inositol-stabilized arginine may be more bioavailable than arginine hydrochloride.


Participants in the study included 10 healthy men, half of whom were given inositol-stabilized arginine, while the other half was given arginine hydrochloride over the course of 15 days. At the end of that 15-day period, the researchers analyzed arginase and ADMA levels. Arginase and ADMA are two enzymes that are known to inhibit arginine levels and nitrous oxide synthesis, respectively.


This was followed by a seven day washout period, after which the participants took the other supplement for another 15 days.


The researchers found that arginase levels were inhibited after the participants took the inositol-stabilized arginine, with no effects on ADMA levels. There were no effects noted for arginine hydrochloride.


Researchers from Nutrition 21 conducted the study. It was presented at the Nutrition 2018 Conference, which took place from June 9 to 12, 2018, in Boston.


Arginine is an amino acid that is a part of most proteins. In the body, it changes into nitric acid. Arginine can be found in gelatin, chocolate, carob, coconut, oats, whole wheat flour, soybeans, and wheatgerm.

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