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This Supplement Combination May Improve Memory, Mood, Cognitive Function in Mature Adults

The results of two early pilot studies suggest that a combination of the supplements soy lecithin-derived phosphatidylserine (PS) and phosphatidic acid (PA) may help improve memory and cognitive function.

Participants in the first study included 72 functioning, non-depressive mature adults with memory problems. Over the course of three months they took three PS/PA capsules containing 300 mg PS and 240 mg PA in total or a placebo daily.

At the conclusion of the study, the researchers found that the PS/PA group had significant improvements in memory and reductions in “winter blues” when compared with the placebo group.

In the second study, 96 patients with Alzheimer’s disease were given the same PS/PA combination or a placebo for two months. At the conclusion of the study, the researchers noted significant stabilizing in daily functioning in the supplement group when compared with the placebo.

The supplement group showed 3.8% deterioration and 90.6% stability in daily functioning while the placebo group came in at 17.9% and 79.5%, respectively. Additionally, 49% of the PS/PA group reported improvements in general condition while only 26.3% of the placebo group reported the same. Lastly, 43% of the PS/PA group continued post-trial supplementation while none of the placebo group chose to do so. No negative side effects were observed

Researchers from Analyze & Realize GmbH in Germany conducted the study. It was published online ahead of print in Advances in Therapy on November 21, 2014.

PS is an essential component of all of our cells membranes, which are essentially the “shells” of our cells. It keeps the cells intact and moves nutrients into them and waste out.

Previous studies suggest that PS may help with declining mental function as well as alleviating depression. Others have found that it may help with thinking ability and improved memory.

PA is often used to increase the effects of strength training as well as improve mental acuity. It is believed that PA enhances the anabolic effects of resistance training.

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