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Supplementation With Ketone May Help Improve Cognitive Function in Obese Adults

People who are obese may be at higher risk for cognitive dysfunction due to reductions in blood flow in the brain. According to a new study, supplementation with ketone containing β-hydroxybutyrate (β-OHB) may help improve brain blood flow and cognitive function in obese adults.

Fourteen obese adults with an average age of 50 participated in the study. They were given 30 mL of ketone supplements or a placebo three time daily for 14 days. Blood supply to the brain, brain blood flow, and blood circulation in the brain were evaluated at baseline and at the end of the study period. Cognitive function was assessed at baseline and at the end of the study period.

Participants in the ketone group saw significant improvements in blood supply, blood flow, and blood circulation in the brain. They also saw improvements in scores on the cognition test.

Ketones are produced by the liver when there is not enough sugar or glucose available to supply the body’s fuel needs. Fats released from fat cells are used by the liver for ketone production.

The study was conducted by researchers from the University of British Columbia Okanagan. The study was published online ahead of print on October 4, 2021 in The Journal of Physiology.

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