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Supplementation with L-citrulline May Provide Cardiovascular Benefits

L-citrulline is an amino acid that helps boost nitric oxide production in the body.  A new study has found that daily supplementation with L-citrulline may support endothelial function and blood pressure in postmenopausal women.

Participants in the study included 25 postmenopausal women with hypertension and an average age of 62. They were given 10 g of L-citrulline or a placebo daily for 4 weeks. The researchers evaluated brachial artery flow-mediated dilation, aortic stiffness, blood pressure, and L-arginine levels at baseline and at the end of the study period.

The L-citrulline group saw a 1.4% increase in brachial artery flow-mediated dilation compared to a 0.5% decrease in the placebo group. Resting aortic diastolic blood pressure decreased by an average 2 mmHg in the L-citrulline group compared to a 2 mmHg increase in the placebo group.

In addition, serum L-arginine levels increased by 13 µmol/L in the L-citrulline group compared to a decrease of 2 µmol/L in the placebo group. Aortic stiffness decreased in the L-citrulline group, although not by a statistically significant amount.

The study was conducted by researchers from Texas Tech University. It was published online ahead of print on October 20, 2022 in the journal Nutrients.

Aronia berry extract was found to support arterial health in a previous study.

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