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Supplement Combination Found To Help Alleviate PMS Symptoms

Premenstrual syndrome (PMS) can begin a week or two before a woman’s period starts, and symptoms may include bloating, headaches, mood swings, or other physical and emotional changes. A new study suggests that supplementation with a combination of oxaloacetate and vitamin C may help alleviate emotional PMS symptoms such as depression, anxiety, perceived stress, aggression, and suicidal ideation.

Participants in the study included 48 women experiencing PMS. They completed a survey at baseline that consisted of the Beck's Depression Inventory, Cohen Perceived Stress Scale, Generalized Anxiety Disorder Test, and Buss-Perry Aggression Questionnaire. They then took 200 mg of oxaloacetate and 300 mg of vitamin C or a placebo daily for the length of their menstrual cycle. Following supplementation, they took the survey again, then switched interventions for an additional menstrual cycle. Oxaloacetate is an organic molecule that is part of the body’s energy production and waste management systems.

The researchers found that supplementation with oxaloacetate and vitamin C significantly reduced emotional PMS symptoms. Specifically, depression was reduced by 54.1%, generalized anxiety was reduced by 51.43%, perceived stress was reduced by 35.8%, aggression was reduced by 17.8%, and suicidal ideation was reduced by 47.9%.

The study was conducted by researchers from the Energy Medicine Research Institute. It was published online ahead of print on February 25, 2020 in the journal Obstetrics & Gynecology Science.

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