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Supplementation With High Dose Vitamin D3 and Omega-3 Linked to Increases in Estradiol in Women

Estradiol is a sex hormone that is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. A new study has found that supplementation with vitamin D3 and omega-3 fatty acids may help increase estradiol and vitamin D levels in vitamin D deficient women.

86 pre-menopausal women who were vitamin D deficient participated in the study. The participants were divided into four groups:

    1. Received 50,000 IU of vitamin D3 once a week;

    1. Received 1,000mg of wild salmon and fish oil containing 300mg of omega-3 once a day;

    1. Received 50,000 IU of vitamin D3 once a week and 1,000mg of wild salmon and fish oil containing 300mg of omega-3 once a day;

    1. Received a placebo


Participants took the supplements for 8 weeks. Fasting serum levels of 25-hydroxy vitamin D and serum estradiol were assessed at baseline and at the end of the study. In addition, mid-follicular serum levels of vitamin D and estradiol were assessed at 8 weeks.

The researchers found that supplementation with vitamin D3 alone resulted in a significant increase in vitamin D levels and a significant decrease in estradiol levels. Supplementation with omega-3 alone resulted in a significant decrease in vitamin D levels and a significant increase in estradiol levels. Supplementation with vitamin D and omega-3 resulted in significant increases in both vitamin D and estradiol.

The study was conducted by researchers from Jordan’s Applied Science Private University and Fakeeh College for Medical Sciences. It was published February 4, 2019 in the journal Clinical Pharmacology: Advances and Applications.
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