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Sustained-Release Caffeine May Offer Benefits of Caffeine Longer Than Immediate-Release Caffeine

A new study has found that a slow and sustained-release caffeine ingredient maintains blood levels of caffeine significantly longer than immediate release caffeine and does not result in a caffeine crash. In addition, it may help sustain alertness and mood for extended periods of time.

Twenty-four males with an average age of 32 participated in the study. They were given a single dose of 200 mg of sustained-release caffeine or 200 mg of immediate-release caffeine. They switched interventions after a 7-day washout period. 

Plasma caffeine levels were measured regularly in the 24 hours following consumption of the caffeine dose. The researchers used the Caffeine-Visual Analogue Scale to evaluate changes in feelings of relaxation, jitteriness, tiredness, tension, headaches, and overall mood from baseline through 12 hours after consuming the caffeine dose.

Consumption of the sustained-release caffeine resulted in a peak in caffeine absorption at approximately 4 hours. This was a 325% increase compared to the immediate-release caffeine, which peaked within the first hour. In addition, caffeine from the sustained-release caffeine remained in the blood 21% longer than then immediate-release caffeine. 

The sustained-release caffeine also resulted in significant beneficial effects on feeling more alert, less tired, less jittery, less tense, and better overall mood compared to the immediate-release caffeine.

The study was conducted by researchers from OmniActive Health Technologies. It was published online ahead of print on April 16, 2021 in the journal Current Research in Behavioral Sciences.

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