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Tocotrienol Form of Vitamin E May Support Bone Health

Previous research has found that oxidative stress and inflammation may play a role in bone loss. A new study suggests that supplementation with vitamin E in the form of delta-tocotrienol may provide bone health benefits in postmenopausal women by reducing oxidative stress and inflammation. 

Eighty-nine postmenopausal women with an average age of 59 participated in the study. They received 300 mg of delta-tocotrienol, 600 mg of delta-tocotrienol, or a placebo daily for 12 weeks. The researchers evaluated bone erosion at baseline and at the end of the study period. They also evaluated levels of serum delta tocotrienol and over 100 biological molecules associated with oxidative stress and inflammation. 

Participants in both delta-tocotrienol groups saw significant reductions in bone erosion. They also saw reductions in biological molecules associated with increased oxidative stress and inflammation and increases in antioxidants that help reduce oxidative stress and inflammation.  Serum levels of delta-tocotrienol were also increased in both groups. 

The study was conducted by researchers from Texas Tech University Health Sciences Center. It was published online ahead of print on December 24, 2021 in the journal Frontiers in Nutrition 

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