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Tocotrienols from Vitamin E Associated With Lower Inflammation and Oxidative Stress

Osteoporosis is characterized by a decrease in the density of bone, which decrease bone strength and results in fragile bones. A recent study suggests that taking a supplement of vitamin E tocotrienols may help lower inflammation and oxidative stress in women with osteoporosis.


Participants in the study included 89 postmenopausal women with osteoporosis and an average age of 60. Over the course of 12 weeks, they were given either an olive oil placebo, 300 mg of vitamin E tocotrienols, or 600 mg of vitamin E tocotrienols.


At the conclusion of the study, the researchers noted significant reductions in levels of 8-hydroxy-2’-deoxyguanosine (8-OHdG), which is a marker for oxidative stress and DNA damage, in the supplement group when compared with the placebo. Specifically, it was reduced by 100% in the 300 mg group and by 150-200% in the 600 mg group.


The 600 mg group also saw lower catabolites of tryptophan, which has been previously linked to reduced inflammation.


Researchers from Texas Tech University Health Sciences Center conducted the study. It was published in the April 2017 issue of FASEB.

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