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Vitamin B Supplementation Shown To Improve Plasma Homocysteine Levels


According to a new study, vitamin B supplementation may help improve endothelial function in people with metabolic syndrome by lowering plasma homocysteine levels.  Endothelial function refers to the health of the endothelium, a thin membrane that lines the heart and blood vessels and plays a central role in the maintenance of vascular function. Many people who have metabolic syndrome also have endothelial dysfunction, which has been linked with increased plasma homocysteine levels.





Participants in the study included 127 people between the ages of 40 and 65. All had at least one component of metabolic syndrome and were not taking any medication for their condition. All the participants were given a beverage that contained B vitamins, and vitamins C, D, and E for two months. They were divided into an early intervention group and a late intervention group.





Researchers measured flow-mediated dilation, plasma homocysteine levels, serum B vitamin levels, and vitamin C levels at baseline and at the end of the study period.





At the end of the study period, there was a significant increase in serum B vitamins and vitamin C levels. There was also a significant reduction in plasma homocysteine levels. The mean serum homocysteine level pre- and post-intervention was 9.8 and 8.2 µmol/L in the early intervention group and 10.8 and 7.4 µmol/L in the later intervention group. No change was seen in flow-mediated dilation.





The study was conducted by researchers from Japan’s Ehime University, Osaka University, Dokkyo Medical University, and Fukushima Medical University. It was published on May 1, 2019 in the Journal of Clinical Biochemistry and Nutrition.


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