Tocotrienol Complex May Help Support Renal Function
A new study has found that supplementation with a vitamin E complex from red palm oil containing the full spectrum of tocotrienols and alpha tocopherol may help improve renal function.
Since Type 2 diabetics frequently struggle with kidney health, the study was conducted with a diabetic population. Fifty-four diabetics with impaired kidney function participated in the study.
Half of them consumed 200 mg of tocotrienol-rich vitamin E twice daily for 12 weeks. The other half took a placebo. Fasting blood samples were taken at baseline, 1 month, 2 months, and 6-9 months post-supplementation. They were used to measure HbA1c, serum creatinine, and the estimated glomerular filtration rate (eGFR).
After 12 weeks, participants in the vitamin E group saw a 3.3 µmol/l decrease in mean serum creatinine levels and an increase of 1.48 ml/min/1.73 m2 in eGFR. The placebo group saw a 5.36 µmol/l increase in mean serum creatinine levels and a decrease in eGFR of 2.89 ml/min/1.73 m2. Lower serum creatinine levels and higher eGFR indicate an improvement in renal function.
Follow-up 9 months after supplementation ended showed that the downward trend in serum creatinine levels continued in the vitamin E group, while levels in the placebo group continued to increase. The biggest improvements in renal function were seen in participants who had low baseline levels of vitamin E.
The study was conducted by researchers from Monash University Malaysia. It was published online ahead of print on December 25, 2019 in the journal Endocrinology and Metabolism.