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Vitamin E Supplementation Associated With Improved Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder. Obesity, insulin resistance, lipid peroxidation, and oxidative stress have been identified as possible precursors to NAFLD. A recent study found that taking the tocotrienol form of vitamin E may help improve symptoms of nonalcoholic fatty liver disease (NAFLD).

Participants in the study included 87 adults with high cholesterol and ultrasound-proven NAFLD. Over the course of one year, half of the group took 200 mg of mixed tocotreniols twice daily and the other half took a placebo.

A total of 64 participants completed the study – 30 in the supplement group and 34 in the placebo group. The researchers noted that while all of the participants had normal blood levels of alpha-tocopherols, the supplement group had higher hepatic echogenic response (improved liver ultrasounds) and a significant rate of remission.

Additionally, NAFLD in two of the placebo participants worsened, while no such cases were recorded in the supplement group.

Researchers from Universiti Sains Malaysia conducted the study. It was published on December 27, 2013, in Nutrition Journal.

Vitamin E has eight different forms: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta) and has been shown to help many aspects of the body. Tocopherol is the most common form in both the American diet and European diets. Tocotrienols are less prominent in the Western diet.

Previous studies have shown that vitamin E intake is associated with lower cholesterol, healthier skin, maintaining a proper hormonal balance, and preventing amyotrophic lateral sclerosis (ALS).

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