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Vitamin K Deficiency Associated With Increased Arterial Stiffness


Matrix GLa protein (MGP) is an inhibitor of arterial stiffness and requires vitamin K for activation. Inactive desphospho-uncarboxylated MGP (dp-ucMGP) is a biomarker of poor vitamin K status. A new study has found an association between higher levels of dp-ucMGP and increased arterial stiffness.





For their study, the researchers looked at the data of 835 people who participated in the Flemish Study on Environment, Genes, and Health Outcomes. The researchers measured levels of dp-ucMGP, central pulse pressure, carotid-femoral pulse wave velocity, and forward and backward pulse waves.





The researchers found that approximately 35% of the participants were vitamin K deficient. Higher levels of dp-ucMGP were associated with higher central pulse pressure, pulse wave velocity, and forward and backward pulse wave, all of which are associated with arterial stiffness and cardiovascular complications.





The study was conducted by researchers from University of Leuven, Belgium. It was published on April 1, 2019 in the Journal of the American Heart Association.


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