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Vitamin K2 Supplementation May Improve Vitamin K Levels, Heart Health in Kidney Transplant Recipients

People who have received kidney transplants often have vitamin K deficiencies. A new study has found that vitamin K2 supplementation may result in improvements in vitamin K deficiencies as well as improved arterial stiffness.


Participants in the study included 60 renal transplant recipients with stable graft function who were given 360 µg/day of vitamin K2 daily for eight weeks. Arterial stiffness was measured using carotid-femoral pulse wave velocity.


After eight weeks of supplementation, the researchers noted significant improvements in arterial stiffness and 24-hour peripheral and central pressures. They noted a 55.1% reduction in dpucMGP levels. High levels of the dpucMGP protein are a biomarker of vitamin K deficiency. They also noted a 14.2% reduction in mean carotid-femoral pulse wave velocity, which is a measure of arterial stiffness.


Researchers from Lebanese American University conducted the study. It was published on July 13, 2017, in the Journal of the American Society of Hypertension.


Previous studies have linked vitamin K2 to bone and cardiovascular health, as well as a reduced risk of prostate cancer. Vitamin K2 can be found in fermented foods such as cheese but can also be found in meat and soybeans. It is also available in supplement form.

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