- Supplements Facts
- Client Reviews
Take Before Carb-Heavy Meals to Support Healthy Blood Sugar Metabolism
InSea2® is a proprietary blend of two USDA certified organic wild brown seaweeds harvested from pure cold waters off Nova Scotia.
These seaweeds were chosen because they’re naturally rich in specific polyphenols that help slow down starch and sugar digestion. This is done by inhibiting some of the activity of the enzymes alpha-amylase and alpha-glucosidase which break down starch and sugar into the glucose that floods the bloodstream.
In two separate clinical studies, a single serving of InSea2® (taken 30 minutes prior to a meal) was shown to reduce the post-meal spike in blood sugar levels.
In the first study, taking InSea2® resulted in a 48% reduction in the post meal blood sugar spike after starch (bread) consumption. In the second study, the decline was 39% after consumption of pure table sugar.
GlucoFit™ is an extract of banaba leaf (also known as crepe myrtle). GlucoFit™ contains corosolic acid and specific tannins that together help support the transfer of glucose from your blood into cells. This helps you maintain normal fasting blood glucose and insulin levels.
Crominex® 3+ uniquely binds chromium to Capros® amla extract and Primavie® shilajit (rich in fulvic acid). This results in superior a form of chromium for two main reasons.
First, it protects the chromium from oxidizing and turning from the desired “3+” form (trivalent) into the potentially harmful “6+” form (hexavalent). Scientific testing has shown that, unlike leading competing chromium brands, Crominex® 3+ does not oxidize and always remains in the desired 3+ trivalent structure.
Second, the chromium in Crominex® 3+ is better absorbed than other leading chromium brands. Plus, in addition to promoting healthy blood sugar and insulin levels, Crominex® 3+ also has been shown to support healthy cholesterol levels and improve markers of oxidative stress.
InSea2®: Help Slow Down Digestion of Both Starch and Sugar
When you eat carbohydrates such as starch and sugar, your body breaks them down into glucose - the simplest carb. Glucose then enters the bloodstream where it can be distributed to cells throughout the body and used as an energy source.
If too much glucose enters the bloodstream at once, the distribution system gets backed up and blood-sugar (glucose) levels spike.
That’s where InSea2® comes in - it doesn’t stop the digestion of carbs, it just helps make the process more orderly. You could think of it as traffic control.
The way InSea2® works is by slowing down the activity of two digestive enzymes responsible for breaking down starch and sugar into glucose. These enzymes are alpha-amylase and alpha-glucosidase.
And this immediately helps reduce the increase in post meal blood sugar. This was shown in a human clinical where taking InSea2® prior to eating starch-filled white bread resulted in a 48.3% reduction in post meal blood glucose levels. In addition, there was significant improvements in insulin secretion and insulin sensitivity measurements.
A second clinical study also found a reduction in post meal blood sugar after ingesting simple table sugar.
InSea2® is believed to be the first nutritional ingredient shown to slow down the digestion of both starch and sugar. As important, unlike some other nutrients, InSea2® doesn’t affect your blood sugar levels, unless you have some carbs to digest.
InSea2® is an exclusive, proprietary blend of two wildcrafted brown seaweeds - Ascophyllum nodosum (kelp) and Fucus vesiculosus (bladder wrack). The seaweed used to make InSea2® is harvested from pure cold waters off Nova Scotia.
These seaweeds were chosen because they’re naturally rich in specific polyphenols that help slow down starch and sugar digestion.
InSea2® is a USDA certified organic ingredient that meets the highest criteria in terms of quality, purity and biological activity.
GlucoFit™: Helps Get Glucose From Blood to Cells
As described above, InSea2® helps slow down and control the amount of sugar that gets into your blood. And once sugar does enter your blood, GlucoFit™ helps get the sugar out and into cells.
GlucoFit™ is an extract of the banaba leaf - which is also known crepe myrtle. The botanical name of banaba is Lagerstroemia speciosa. The leaves from this tree have been used for many years in traditional medicine to aid blood sugar health in Southeast Asia - most notably in the Philippines.
GlucoFit™ contains ample amounts of both compounds from banaba leaves that support blood sugar health - corosolic acid and ellagitannins (which are polyphenols).
Your body mainly relies on the hormone insulin to transport glucose from the bloodstream to muscle and fat cells. However, over reliance on insulin can make it less effective over time. As a result, maintaining normal insulin levels is a key part of long term blood sugar health.
GlucoFit™ has been shown to help support healthy insulin levels - and consequently promote blood sugar health. Banaba is believed to work by helping to activate proteins in cells that transport glucose from blood to the cells.
Corosolic acid was found to activate these proteins in muscle cells, while ellagitannins were shown to work in fat cells - hence why you want both types of nutrients, which GlucoFit™ provides.
By increasing the number of active glucose transporters at the edge of cells ready to greet glucose in blood, GlucoFit™ supports the function of insulin in the body and contributes to healthier blood sugar levels.
This was demonstrated in a clinical study involving adults that was published in the Journal of Ethno-Pharmacology. GlucoFit™ was shown to make a significant difference in as little as 15 days.
Crominexr 3+: Safer and Better Absorbed Too!
If GlucoFit™ is the ingredient that helps unlock the cell doors so glucose can get inside, Crominex® 3+ (a patented chromium ingredient) is the ingredient that cranks that door wide, wide open.
Chromium is a trace mineral that helps move blood sugar (glucose) from the bloodstream and into cells where it can be used as energy. It plays an important role in supporting the body in converting fats, carbohydrates, and proteins into energy.
Signs that you may not be getting adequate chromium include elevated blood glucose, insulin and cholesterol.
Elemental chromium exists in two basic forms. One is called chromium 3+, (trivalent chromium) which is the essential nutrient you need and is found in foods like grains and vegetables. The other is chromium 6+ (hexavalent chromium) and it can be toxic.
If you remember the movie Erin Brockovich, chromium 6+ was the focus point of the story and litigation. A California utility was using chromium 6+ to fight corrosion of its equipment and it leaked into the local water supply. The court ruled that this contamination contributed to various illnesses suffered by local residents.
While most supplements use a chromium compound that starts off as chromium 3+, scientific testing has that shown many products are vulnerable to oxidation, which transforms some of the chromium 3+ into the harmful chromium 6+.
Indeed this was shown to be the case with two of the leading chromium ingredients - chromium picolinate and chromium nicotinate. The absence of adequate antioxidant protection resulted in the presence of some chromium 6+ in tested samples.
That’s why in TrueGluco SP™ we use the Crominex® 3+ brand of chromium. Unlike the types of chromium many supplement manufacturers use, Crominex® 3+ is protected by potent antioxidants that shield it from becoming the toxic 6+ form.
With Crominex® 3+, the chromium 3+ is wrapped in a protective bubble of Capros® - a natural extract from amla berry - and a a purified mineral complex from deep in the Himalayan mountains called Primavie®.
This combination fully insulates the chromium 3+ so it won’t oxidize into the harmful form. What’s more, it enhances the absorption of chromium. In fact, about 60% of the chromium in Crominex® 3+ is absorbed into the body, which is 20% better than chromium picolinate and chromium nicotinate.
And Crominex® 3+ works just as well at supporting healthy blood sugar. In fact, in head-to-head testing, all three chromium ingredients produced about a 5% improvement in fasting blood sugar in individuals who were just out of the normal range. These folks began the trial averaging around 105mg/dl and after 12 weeks of taking 400mcg of chromium daily they improved to about 100mg/dl.
But the real surprise was the other benefits experienced from taking Crominex® 3+, but not with the other chromium ingredients.
For example with Crominex® 3+, there was a 13% improvement in LDL cholesterol (improving 109mg/dl to 94mg/dl).
With regards to the inflammatory marker hsCRP (C-reactive protein), those taking Crominex® 3+, experienced a remarkable 39% improvement, going from 3.3mcg/L to 1.9mcg/L.
A 19% improvement in nitric oxide (NO) in the blood was also noted, improving from 28.5mm/L to 33.8 mm/L.
Finally, there was a significant improvement in antioxidant markers. An example of this was the measure of glutathione (GSH) in the blood. GSH increased by about 14% from 369mm/L to 420mm/L after the 12 week period.
This data further validates that Crominex® 3+ is the superior chromium ingredient. Not only will it not oxidize into harmful chromium 6+, and supports blood sugar health, Crominex® 3+ offers other cardiovascular and antioxidant benefits.
Dietary Supplement / 60 Capsules
Serving Size: 1 Capsule
Servings per Container: 60
|Per Serving||Per Day (2 capsules)|
|Amount||% Daily Value||Amount||% Daily Value|
|Vitamin D [as vitamin D3 (cholecalciferol)]||200 IU||50%||400 IU||100%|
|Biotin||500 mcg||167%||1000 mcg||333%|
|Iodine [from Algae polyphenols (InSea2™)]||250 mcg||167%||500 mcg||333%|
|Zinc (as zinc glycinate)||4 mg||27%||8 mg||53%|
|Chromium (as Crominexr 3+ chromium complex with Phyllanthus emblica fruit and purified shilajit)||200 mcg||167%||400 mcg||333%|
|InSea2™ (algae polyphenols)||250 mg||*||500 mg||*|
|GlucoFit™ banaba leaf extract (Lagerstroemia speciosa)||24 mg||*||48 mg||*|
|Vanadyl sulfate||80 mcg||*||160 mcg||*|
|Gymnema leaf extract (75% gymnemic acids)||33.3 mg||*||66.6 mg||*|
* Daily value not established.
Other ingredients: Gelatin, dicalcium phosphate, vegetable stearic acid and silica.
TrueGlucoSP™ helps support healthy blood sugar levels when taken 30 minutes prior to meals.† TrueGlucoSP™ features three clinically proven ingredients, InSea2™, GlucoFit™ and Crominexr 3+, as well as supporting nutrients.†
Take one capsule 30 minutes prior to your two largest meals (meals that contain the largest amount of carbohydrates). Alternatively, you can take two capsules before a single carbohydrate rich meal (such as bread or pasta). Do not exceed four capsules per day.
Keep out of reach of children.
Store at 15-30° C (59-86° F).
Protect from heat, light and moisture.
Do not purchase if seal is broken.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- Gluten Free
- Assembled in the USA
Manufactured for and Distributed by: NatureCity®
Boca Raton, FL 33487 www.naturecity.com
To re-order call toll free 1-800-593-2563
Bérubé J, Millette E, Paradis ME, Couture P, Lamarche B, Anguenot R. L’Integratore Nutrizionale, 2014 Jun; 17(2): 24-9.
Paradis ME, Couture P, Lamarche B. Applied Physiology, Nutrition, and Metabolism. 2011 Dec;36(6):913-9.
Other Brown seaweed (Ecklonia cava)
Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK. Journal of Medicinal Food. 2012 Nov;15(11):1038-44.
Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ. Phytotherapy Research. 2012 Mar;26(3):363-8.
Judy W, Hari S, Stogsdill W, Judy J, Naguib Y, Passwater R. (2003). Journal of Ethnopharmacology. Volume 87, Issue 1, July 2003, Pages 115–117.
Other Banaba Leaf Extract (Lagerstroemia speciosa)
Cicero AF, Colletti A. Phytomedicine. 2015 Dec 11. pii: S0944-7113(15)00361-X.
Stohs SJ, Miller H, Kaats GR. Phytotherapy Research. 2012 Mar;26(3):317-24.
Haibing X. Chinese Center for Disease Control and Prevention, Beijing Hospital. June 13, 2008. Unpublished study.
Tsuchibe S, Kataumi S, Mori M, Mori H. Journal for the Integrated Study of Dietary Habits, vol. 17, pp. 255–259, 2006.
Ikeda Y, Chen JT, Matsuda T. Japanese Pharmacology and Therapeutics. 1999;27(5):828-835.
Rani U, Sravanti I.V., Fatima N, Muralidhar N. (2014) Unpublished data.
Rani U, Sravanti I.V., Fatima N, Muralidhar N. (2013) Unpublished data.
Rani U, Kumar U, Kishore K, Sravanti I.V., Fatima N, Muralidhar N. (2012) Unpublished data.
Rani U, Kumar U, Kishore K, Sravanti I.V., Fatima N, Muralidhar N, . Rani U, Kumar U, Kishore K, Sravanti I.V., Fatima N, Muralidhar N. (2012) Unpublished data.” (2012) Unpublished data.
Biswas TK, Polley G, Pandit S, Pratip DK, Somoresh M, Biswajit A, Shibnath G. International Journal of Diabetes in Developing Countries. July-September 2010 | Volume 30 | Issue 3: 153-161.
Ghosal S, Bhattacharyya S. Natreon Inc., July 2006 Unpublished data.
Abdollahi M, Farshchi A, Nikfar S, Seyedifar M. Journal of Pharmacy & Pharmaceutical Sciences. 2013;16(1):99-114.
Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Journal of Trace Elements in Medicine and Biology. 2011 Jul;25(3):149-53.
Wang ZQ, Qin J, Martin J, Zhang XH, Sereda O, Anderson RA, Pinsonat P, Cefalu WT. Metabolism. 2007 Dec;56(12):1652-5.
Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, Cefalu WT. Diabetes Care. 2006 Aug;29(8):1826-32.
Racek J, Trefil L, Rajdl D, Mudrová V, Hunter D, Senft V. Biological Trace Element Research. 2006 Mar;109(3):215-30.
Frauchiger MT, Wenk C, Colombani PC. The Journal of the American College of Nutrition. 2004 Aug;23(4):351-7.
Ghosh D, Bhattacharya B, Mukherjee B, Manna B, Sinha M, Chowdhury J, Chowdhury S. The Journal of Nutritional Biochemistry. 2002 Nov;13(11):690-697.
Althuis MD, Jordan NE, Ludington EA, Wittes JT. American Journal of Clinical Nutrition, 2002; 76:148-55.
Anderson RA, Cheng N, Bryden NA, Polansky MM, Chi J, Feng J. Diabetes. 1997 Nov;46(11):1786-91.
Oguma S, Ando I, Hirose T, Totsune K, Sekino H, Sato H, Imai Y, Fujiwara M. Tohoku J Exp Med. 2012;227(3):217-23.
Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Diabetes/Metabolism Research and Reviews. 2008 Jan-Feb;24(1):41-51.
Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR. Journal of the Cardiometabolic Syndrome. 2007 Spring;2(2):91-7.
Geohas J, Daly A, Juturu V, Finch M, Komorowski JR. The American Journal of the Medical Sciences. 2007 Mar;333(3):145-53.
Singer GM, Geohas J. Diabetes Technology & Therapeutics. 2006 Dec;8(6):636-43.
Revilla-Monsalve C, Zendejas-Ruiz I, Islas-Andrade S, Báez-Saldaña A, Palomino-Garibay MA, Hernández-Quiróz PM, Fernandez-Mejia C. Biomedicine & Pharmacotherapy. 2006 May;60(4):182-5.
Zhou J, Chen H, Wang Z, Li Y, Li M, Xiang H. Zhonghua Yi Xue Za Zhi. 2014 Nov 25;94(43):3407-10.
Nasri H, Behradmanesh S, Maghsoudi AR, Ahmadi A, Nasri P, Rafieian-Kopaei M. Journal of Renal Injury Prevention. 2013 Nov 30;3(1):31-4.
Talaei A, Mohamadi M, Adgi Z. Diabetology & Metabolic Syndrome. 2013 Feb 26;5(1):8.
Nazarian S, St Peter JV, Boston RC, Jones SA, Mariash CN. Translational Research. 2011 Nov;158(5):276-81.
Nikooyeh B, Neyestani T, Farvid M, Alavi-Majd H, Houshiarrad A, Kalayi A, Shariatzadeh N, Gharavi A, Heravifard S, Tayebinejad N, Salekzamani S, Zahedirad M. American Journal of Clinical Nutrition. April 2011 vol. 93 no. 4 764-771.
von Hurst PR, Stonehouse W, Coad J. British Journal of Nutrition. 2010 Feb;103(4):549-55.
Witham MD, Dove FJ, Dryburgh M, Sugden JA, Morris AD, Struthers AD. Diabetologia. 2010 Oct;53(10):2112-9.
Ozfirat Z, Chowdhury TA. Postgraduate Medical Journal. 2010 Jan;86(1011):18-25.
Alvarez JA, Ashraf A. International Journal of Endocrinology. 2010: 351385. Published online 2009 Aug 19.
Nagpal J, Pande JN, Bhartia A. Diabetic Medicine. 2009 Jan;26(1):19-27.
Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R. International Journal of Clinical Practice. 2003 May;57(4):258-61.
Kim J, Ahn J. Biological Trace Element Research. 2014 Feb;157(2):101-6.
Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, Poursafa P, Rouzbahani A. Metabolic Syndrome and Related Disorders. 2010 Dec;8(6):505-10.
Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N, Amini M, Tavakoli N, Movahedian-Attar A, Mirmoghtadaee P, Poursafa P. Hormones (Athens). 2009 Oct-Dec;8(4):279-85.
Al-Maroof RA, Al-Sharbatti SS. Saudi Medical Journal. 2006 Mar;27(3):344-50.
Roussel A, Kerkeni A, Zouari N, Mahjoub S, Matheau J, Anderson R. The Journal of the American College of Nutrition. 2003 Aug;22(4):316-21.
Anderson R, Roussel A, Zouari N, Mahjoub S, Matheau J, Kerkeni A. The Journal of the American College of Nutrition. 2001 Jun;20(3):212-8.
Gupta R, Garg VK, Mathur DK, Goyal RK. Journal of the Association of Physicians of India. 1998 Nov;46(11):939-42.
Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P. Journal of the Science of Food and Agriculture. 2014 Mar 30;94(5):834-40.
Kumar SN, Mani UV, Mani I. Journal of Dietary Supplements. 2010 Sep;7(3):273-82.
Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Journal of Ethnopharmacology. 1990 Oct;30(3):295-300.
Willsky GR, Halvorsen K, Godzala ME 3rd, Chi LH, Most MJ, Kaszynski P, Crans DC, Goldfine AB, Kostyniak PJ. Metallomics. 2013 Nov;5(11):1491-502.
Soveid M, Dehghani GA, Omrani GR. Archives of Iranian Medicine. 2013 Jul;16(7):408-11.
Sakurai H. The Chemical Record. 2002;2(4):237-48.
Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC. The Journal of Clinical Endocrinology and Metabolism. 2001 Mar;86(3):1410-7.
Boden G, Chen X, Ruiz J, van Rossum GD, Turco S. Metabolism. 1996 Sep;45(9):1130-5.
*The views and opinions expressed by contributors and or product reviews are their own and not
necessarily those of NatureCity. These reviews should not be taken as recommendations but rather
client opinions of the products that they have used.