- Product Partners
- Supplements Facts
- Scientific References
- Client Reviews
5-in-1 Approach to Supporting Energy and Blood Flow Boosting Nitric Oxide!
How could a gas that’s a known air pollutant be crucial to your health?
This had many people in the medical community scratching their heads – until a discovery about the importance of this gas resulted in a Nobel Prize in Medicine award in 1998.
The gas is nitric oxide, and it helps your blood vessels relax and widen promoting healthy blood flow and vessel flexibility.
Healthy nitric oxide levels are needed to support many aspects of health – from cardiovascular and optimal brain function, to sexual health… and also to help fight off fatigue and maintain high energy levels.
Our bodies produce nitric oxide just fine for the first 30 years of our lives – and then nitric levels decline rapidly with age.
By the time you reach age 50, it’s not unusual for nitric oxide levels to decline by 60%. And by age 70, nitric oxide levels can be down 90% from peak levels!
TrueNOx™ is a unique 5-in-1 approach to help you maintain healthy nitric oxide levels. Together, the five ingredients in this sugar-free drink powder help boost nitric oxide levels from the very first glass – working right away to boost blood flow, energy and endurance levels.
For best results, drink TrueNOx™ about 30 minutes prior to physical activity. This can be exercise, walking or anything else that can benefit from increased blood flow and energy (yes, even “romantic time”).
Better yet, there is no sugar, caffeine or stimulants in TrueNOx™!
Here’s a quick rundown on the five key ingredients that make TrueNOx™ the best nitric oxide formula we’ve seen…
Nitrosigine® - one of the building blocks for nitric oxide is the aminio acid L-arginine. That’s why many other supplements feature arginine in their formula. The problem is you need many grams of arginine to see an improvement - and many folks still don’t benefit.
Nitrosigine® is a patented complex of arginine bonded to silicon that has been shown to be far superior to other forms of arginine.
Not only has it been shown to increase nitric oxide, 19 scientific studies have demonstrated it enhances performance by promoting blood flow and increasing focus and energy.
Nitrosigine® starts to work in as little as 15 minutes and single dose effects can last up to six hours.
Capros® - made from the amla fruit, Capros® is a nice compliment to Nitrosigine®.
Your body converts arginine to nitric acid with the help of certain enzymes – most notably the enzyme abbreviated as “eNOS.”
One of numerous cardiovascular benefits of Capros is it promotes and activates eNOS, resulting in increased nitric oxide levels.
This was shown in three separate clinical studies where taking 500mg a day of Capros® increased nitric oxide levels by an average of 35% after 12 weeks.
Plus, those taking Capros® also experienced significant improvements in oxidative stress, lipid and glutathione levels and a marker of inflammation (hsCRP).
Organic Beet Root - Another way your body produces nitric oxide is by converting dietary nitrates into nitric oxide. That’s why TrueNOx™ also includes 1,000mg of organic beet root juice powder from Vibrant Harvest.
Beet root juice is a good source of nitrates and clinical studies have shown it helps promote nitric oxide and improves blood flow, endurance and performance.
Crominex® 3+ - This is a special form of the mineral chromium. Unlike other forms of chromium, Crominex® 3+ has been shown to help the endothelium – which is the cells that line the inner surface of blood vessels throughout the entire circulatory system.
It works, in part, by promoting nitric oxide levels. In two clinical studies involving Crominex® 3+, middle aged participants taking 400mcg daily had improved nitric oxide levels by about 20% to 30% after 12 weeks.
PEAK ATP® - provides an immediate boost to energy, blood flow and endurance levels during physical activity – while supporting vasodilation factors like nitric oxide.
ATP is a building block for cellular energy. In a recent clinical study, a single 400mg dose of PEAK ATP® increased physical performance during exercise by 24%.
Over 12 weeks, PEAK ATP® has been shown to improve blood flow, lean body mass, strength and reduce muscular fatigue.
Dietary Supplement / Net Wt. 5.1 oz (144 g)
Serving Size: 1 scoop (4.8 g)
Servings per Container: 30
|Amount Per Serving||% Daily Value|
|Total Carbohydrate||2 g||<1%*|
|Total Sugars||<1 g||**|
|Chromium [as chromium complex with Phyllanthus emblica fruit and purified shilajit (Crominex® 3+)]||400 mcg||1,143%|
|Nitrosigine® (Inositol-Stabilized Arginine Silicate)||1.5 g||**|
|Organic beet root juice powder||1 g||**|
|Capros® Amla Fruit Extract (Phyllanthus emblica) (standardized to minimum 60% tannins)||500 mg||**|
|PeakATP® (adenosine 5'-triphosphate disodium)||400 mg||**|
*Percent Daily Values are based on a 2,000 calorie diet.
** Daily value not established.
Other ingredients: citric acid, natural flavors, silica, stevia blend (rebaudioside A & steviol glycosides) and beet root (for color).
Nitrosigine® is a registered trademark of Nutrition 21, LLC., and is protected by U.S. patents: #5,707,970; #6,156,735; #6,344,444; and #7,576,132. / PEAK ATP® is a registered trademark of TSI USA Inc. and is used under license. / Capros® and Crominex® 3+ are a registered trademark of Natreon, Inc.
Directions: Add one (1) scoop to 8 fl. oz of water and stir. For best results, take 30 to 60 minutes prior to exercise or physical activity.
TrueNOx™ helps to promote healthy nitric oxide levels, boost energy levels, blood flow and endurance. Helps to reduce fatigue and support muscle recovery after physical activity. Supports normal cardiovascular and cognitive function.†
Keep out of reach of children.
Store at 15-30° C (59-86° F).
Protect from heat, light and moisture.
Do not purchase if seal is broken.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- Assembled in the USA
- BPA Free
Manufactured for and Distributed by: NatureCity®
Boca Raton, FL 33487 www.naturecity.com
To re-order call toll free 1-800-593-2563
Kalman D, Hewlings S, Sylla S, Perez Ojalvo S, Komorowski J. “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine®) on cognitive flexibility.” Journal of the International Society of Sports Nutrition. 2018.
Evans M, Zakaria N, Marzuk M, Perez Ojalvo S, Sylla S, Komorowski J. “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine®) in preventing the decline in cognitive function caused by strenuous exercise.” Journal of the International Society of Sports Nutrition.2018
Komorowski J, Perez Ojalvo S, Sylla S, Veledar E. “Arginase inhibition by inositol-stabilized arginine silicate (ASI; Nitrosigine®); a novel mechanism by which ASI enhances arginine bioavailability.” Current Developments in Nutrition. Date 2018.
Komorowski J, Perez Ojalvo S. “A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males.” The FASEB Journal. 2016; 30(1) Supplement 690.17.
Rood-Ojalvo S, Sandler D, Veledar E, Komorowski J. “The benefits of inositol-stabilized arginine silicate as a workout ingredient”. Journal of the International Society of Sports Nutrition. 2015; 12(Suppl 1):P14..
Kalman D, Feldman S, Samson A, Krieger D. “A clinical evaluation to determine the safety pharmacokinetics and pharmacodynamics of an inositol stabilized arginine silicate dietary supplement in healthy adult males.” The Journal of Clinical Pharmacology. 2015;7:103-109.
Komorowski J, Rood-Ojalvo S, El-Sohemy A. “Arginine silicate supplementation decreases markers of cardiovascular, renal and metabolic dysfunction and increases markers of vasodilation and cardiovascular health in healthy adult males”. FASEB Journal. 2015; 29:748.2.
N21 H, 2015: “A randomized, double-blind, placebo-controlled trial to determine the effects of Nitrosigine® on lean body mass and arm circumference in weight-training adult males.” (N21 Data on file)
Kalman DS, Feldman S, Samson A, Krieger DR. “A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males.” FASEB Journal. 2014; 28:LB 418.
Proctor SD, Vine DF, Russell JC. “Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese insulin-resistant JCR: LA-cp rat”. Metabolism: Clinical and Experimental. 2007; (56):1318-1325.
Proctor SD, Vine DF, Russell JC. “A novel complex of arginine-silicate improves micro and macrovascular function and inhibits glomerular sclerosis in insulin-resistant JCR:LA-cp rats.” Diabetologia 2005; 48:1925-1932.
Khanna S, Das A, Spieldenner J, Rink C, Roy S. “Supplementation of a Standardized Extract from Phyllanthus emblica Improves Cardiovascular Risk Factors and Platelet Aggregation in Overweight/Class-1 Obese Adults.” Journal of Medicinal Food. 2015 18 (4) 415-420.
Fatima N, Pingali U, Muralidhar N. “Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus.” Phytomedicine. 2014 Apr 15;21(5):579-85.
Fatima N, Pingali U, Pilli R. "Capros may mitigate cold pressor stress induced cardiovascular changes." Pharmacognosy Research, January-March 2014, Volume 6, Issue 1, pp 29-35.
Pingali U, Fatima N, Muralidhar N. “Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. July 2013 Volume 2013:6 Pages 275-284.
Usharani P, Fatima N, Muralidhar N: “Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: A randomized, double-blind, controlled study.” Diabetes Metab Syndr Obes 2013;6:275–284.
Usharani P, Kishan PV, Fatima N, Kumar UC: “A comparative study to evaluate the effect of highly standardised aqueous extracts of Phyllanthus emblica, withania somnifera and their combination on endothelial dysfunction and biomarkers in patients with type II diabetes mellitus.” Int J Pharm Sci Res 2014;5: 2687–2697.
Usharani P, Sravanti IV. “Evaluation of effect of Emblica officinalis (Capros) on mental stress induced cardiovascular changes in healthy human subjects” Awaiting publication
Usharani P, et. al.: “Study of Capros and Placebo on Endothelial dysfunction in Metabolic syndrome” Department of Clinical Pharmacology and Therapeutics Nizam’s Institute of Medical Sciences Punjagutta, Hyderabad, Andhra Pradesh, India. Awaiting publication
Biswas TK, Cakrabarti S, Pandit S, Jana U, Dey SK. “Clinical evaluation of a Standardized extract of Emblica officinalis fruits for improvement of cardio-respiratory and antioxidant status of volunteers with long smoking history” Awaiting publication
Rani U, Sravanti I.V., Fatima N, Muralidhar N. “Study of Crominex 200mcg, 400mcg and Placebo on Endothelial dysfunction in subjects with Metabolic Syndrome.” (2014) Unpublished data.
Rani U, Sravanti I.V., Fatima N, Muralidhar N. “Study of Crominex 200mcg, 400mcg and Placebo in modifying cardiovascular risk with special reference to Endothelial dysfunction in patients with Type2 Diabetes Mellitus” (2013) Unpublished data.
Rani U, Kumar U, Kishore K, Sravanti I.V., Fatima N, Muralidhar N, . “Evaluation of the effect of Chromium chloride 400 mcg, Phyllanthus emblica 100 mg+Shilajit 100 mg, Chromium picolinate 400 mcg, Chromium polynicotinate 400 mcg andChromium dinicocysteinate 400mcg on endothelial dysfunction in subjects with Type2Diabetes mellitus” (2012) Unpublished data.
Rani U, Kumar U, Kishore K, Sravanti I.V., Fatima N, Muralidhar N, . “Rani U, Kumar U, Kishore K, Sravanti I.V., Fatima N, Muralidhar N, . “Evaluation of the effect of Chromium chloride 400 mcg, Phyllanthus emblica 100 mg+Shilajit 100 mg, Chromium picolinate 400 mcg, Chromium polynicotinate 400 mcg andChromium dinicocysteinate 400mcg on endothelial dysfunction in subjects with Type2Diabetes mellitus” ” (2012) Unpublished data.” (2012) Unpublished data.
Biswas TK, Polley G, Pandit S, Pratip DK, Somoresh M, Biswajit A, Shibnath G.. “Effects of adjunct therapy of a proprietary herbo-chromium supplement in type 2 diabetes: A randomized clinical trial.” International Journal of Diabetes in Developing Countries. July-September 2010 | Volume 30 | Issue 3: 153-161.
Ghosal S, Bhattacharyya S. “Quantitative estimation of trivalent (Cr3+) and hexavalent chromium (Cr6+) in different chromium supplements, before and after oxidative condition, by HPTLC and UV-Vis spectrophotometer.” Natreon Inc., July 2006 Unpublished data.
Freitas M.C. et al. “Single dose of oral ATP supplementation improves performance and physiological response during lower body resistance exercise in recreational resistance trained males.” Journal of Strength & Conditioning Research 2017, Oct 16.
Purpura M, et al. “Oral Adenosine-50-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout.” Journal of the American College of Nutrition. 2017 36:3, 177-183.
Wilson JM, et al. “Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men.” Nutrition & Metabolism 2013 10:57.
Jäger R et al. “Oral adenosine-5'-triphosphate (ATP) administration improves blood flow following exercise in animals and humans.” Journal of the International Society of Sports Nutrition. 2014, 11:28.
Long, Gong et al. “Effects of Adenosine Triphosphate (ATP) on Early Recovery After Total Knee Arthroplasty (TKA): A Randomized, Double-Blind, Controlled Study.” The Journal of Arthroplasty. 2014, Volume 29, Issue 12, 2347 – 2351.
Lowery RP, et al. “Oral ATP administration improves blood flow responses to exercise in both animal and human training models.” Presented at 10th Annual ISSN Conference. Colorado Springs, CO. June 2013.
Rathmacher JA et al. “Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets.” Journal of the International Society of Sports Nutrition.2012, 9:48.
Jonvik K.L., Nyakayiru J., Van Dijk J.W., Maase K., Ballak S.B., Senden J.M.G., L.J.C. Van Loon L.J.C.,Verdijk L.B. “Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes.” European Journal of Sport Science. 2018, 18:4, 524-533.
Clifford T, Howatson G, West DJ, Stevenson EJ. “Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise.” Applied Physiology, Nutrition and Metabolism. 2017 Nov;42(11):1185-1191.
Nyakayiru J, Jonvik KL, Trommelen J, Pinckaers PJ, Senden JM, van Loon LJ, Verdijk LB. “Beetroot Juice Supplementation Improves High-Intensity Intermittent Type Exercise Performance in Trained Soccer Players.” Nutrients. 2017 Mar 22;9(3).
Flueck, J.L.; Bogdanova, A.; Mettler, S.; Perret, C. “Is beetroot juice more effective than sodium nitrate? The effects of equimolar nitrate dosages of nitrate-rich beetroot juice and sodium nitrate on oxygen consumption during exercise.” Applied Physiology, Nutrition and Metabolism. 2016, 41, 421–429.
Thompson, C.; Wylie, L.J.; Fulford, J.; Kelly, J.; Black, M.I.; McDonagh, S.T.; Jeukendrup, A.E.; Vanhatalo, A.; Jones, A.M. “Dietary nitrate improves sprint performance and cognitive function during prolonged intermittent exercise.” European Journal of Applied Physiology. 2015, 115, 1825–1834.
Breese, B.C.; McNarry, M.A.; Marwood, S.; Blackwell, J.R.; Bailey, S.J.; Jones, A.M. “Beetroot juice supplementation speeds O2 uptake kinetics and improves exercise tolerance during severe-intensity exercise initiated from an elevated baseline.” American Journal of Physiology-Regulatory. Integrative and Comparative Physiology. 2013, 305, R1441–R1450.
Hoon, M.W.; Jones, A.M.; Johnson, N.A.; Blackwell, J.R.; Broad, E.M.; Lundy, B.; Rice, A.J.; Burke, L.M. “The Effect of Variable Doses of Inorganic Nitrate-Rich Beetroot Juice on Simulated 2000 m Rowing Performance in Trained Athletes.” International Journal of Sports Physiology and Performance. 2013, 9, 615–620.
Wylie, L.J.; Mohr, M.; Krustrup, P.; Jackman, S.R.; Ermiotadis, G.; Kelly, J.; Black, M.I.; Bailey, S.J.; Vanhatalo, A.; Jones, A.M. “Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance.” European Journal of Applied Physiology. 2013, 113 , 1673–1684.
Cermak, N.M.; Res, P.; Stinkens, R.; Lundberg, J.O.; Gibala, M.J.; van Loon, L.J. “No improvement in endurance performance after a single dose of beetroot juice.” International Journal of Sport Nutrition and Exercise Metabolism. 2012, 22, 470–478.
Cermak, N.; Gibala, M.; van Loon, L. “Nitrate supplementation improves 10 km time trial performance in trained cyclists.” International Journal of Sport Nutrition and Exercise Metabolism. 2011, 22, 64–71.
Lansley, K.E.; Winyard, P.; Bailey, S.; Vanhatalo, A.; Wilkerson, D.; Blackwell, J.; Gilchrist, M.; Benjamin, N.; Jones, A. “Acute dietary nitrate supplementation improves cycling time trial performance.” Medicine & Science in Sports & Exercise. 2011, 43, 1125–1131.
Bailey, S.J.; Winyard, P.; Vanhatalo, A.; Blackwell, J.R.; Dimenna, F.J.; Wilkerson, D.P.; Tarr, J.; Benjamin, N.; Jones, A.M. “Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.” Journal of Applied Physiology. 2009, 107, 1144–1155.
*The views and opinions expressed by contributors and or product reviews are their own and not
necessarily those of NatureCity. These reviews should not be taken as recommendations but rather
client opinions of the products that they have used.